N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

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Chemical Name:N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride
CAS No.:928038-32-8
Molecular Formula:C₂₂H₁₈F₂N₄O₃*ClH
Molecular Weight:460.868
Hs Code.:

Synonyms:N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

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Chemical Property of N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

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Technology Process of N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

There total 3 articles about N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.9%

: 928038-30-6
4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

: 928038-32-8
N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

Guidance literature:: 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide; With pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene; In N,N-dimethyl-formamide; at 20 ℃; for 33h;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

: 99586-65-9
4-chloropicolinamide

: 928038-32-8
N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

1.2: 110 - 120 °C

2.1: pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene / N,N-dimethyl-formamide / 33 h / 20 °C

With pyridine; potassium tert-butylate; water; bis-[(trifluoroacetoxy)iodo]benzene; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 757251-54-0
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide

: 928038-32-8
N-{4-[(2-Aminopyridin-4-yl)oxy]-2-fluorophenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / 0 °C

1.2: 1.5 h / 0 °C

1.3: 0 - 20 °C

2.1: pyridine; water; bis-[(trifluoroacetoxy)iodo]benzene / N,N-dimethyl-formamide / 33 h / 20 °C

With pyridine; water; triethylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; N,N-dimethyl-formamide;