4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

Base Information

Chemical Name:4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide
CAS No.:928038-30-6
Molecular Formula:C₂₃H₁₈F₂N₄O₄
Molecular Weight:452.417
Hs Code.:

Synonyms:4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

Suppliers and Price of 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

There total 4 articles about 4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.43%

: 757251-54-0
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide

: 928038-30-6
4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

Guidance literature:: ((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.25h;

With thionyl chloride; In tetrahydrofuran; at 0 ℃; for 1.5h;

4-(4-amino-3-fluorophenoxy)pyridine-2-carboxyamide; With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield: 29.0%

: 99586-65-9
4-chloropicolinamide

: 1051433-65-8
N-(2-fluoro-4-hydroxyphenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 928038-30-6
4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

Guidance literature:: N-(2-fluoro-4-hydroxyphenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h; Inert atmosphere;

4-chloropicolinamide; In 1-methyl-pyrrolidin-2-one; at 110 - 120 ℃; Inert atmosphere;

Reference yield: 29.0%

: 99586-65-9
4-chloropicolinamide

: 928038-30-6
4-(3-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl] amino }phenoxy)pyridine-2-carboxamide

Guidance literature:: N-(2-fluoro-4-hydroxyphenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide; With potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h;

4-chloropicolinamide; In 1-methyl-pyrrolidin-2-one; at 110 - 120 ℃; Product distribution / selectivity;