1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

Base Information

Chemical Name:1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne
CAS No.:76049-52-0
Molecular Formula:C24H14ClNO3
Molecular Weight:399.833
Hs Code.:
DSSTox Substance ID:DTXSID901146836

Synonyms:1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne;SCHEMBL10992167;MPXCXAKEUVBVIE-UHFFFAOYSA-N;DTXSID901146836;76049-52-0;2-[3-(2-Benzoyl-4-chlorophenyl)-2-propyn-1-yl]-1H-isoindole-1,3(2H)-dione

Suppliers and Price of 1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:399.0662210
Heavy Atom Count:29
Complexity:705

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C(=O)C2=C(C=CC(=C2)Cl)C#CCN3C(=O)C4=CC=CC=C4C3=O

Technology Process of 1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne

There total 4 articles about 1-[4-Chloro-2-benzoylphenyl]-3-phthalimidopropyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 7223-50-9
N-propargylphthalimide

: 76049-48-4
5-chloro-2-iodobenzophenone

: 76049-52-0
1-[4-chloro-2-benzoylphenyl]-3-phthalimidopropyne

Guidance literature:: With copper(l) iodide; diethylamine; triphenylphosphine; palladium dichloride; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jo00133a040

Reference yield:

: 7223-50-9
N-propargylphthalimide

: 76049-48-4
5-chloro-2-iodobenzophenone

: 109-89-7
diethylamine

: 76049-52-0
1-[4-chloro-2-benzoylphenyl]-3-phthalimidopropyne

Guidance literature:: With copper(I) iodide; triphenylphosphine; palladium(II) chloride; In dichloromethane; isopropyl alcohol;

Reference yield:

: 719-59-5
5-chloro-2-aminobenzophenone

: 76049-52-0
1-[4-chloro-2-benzoylphenyl]-3-phthalimidopropyne

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium nitrite, conc. sulfuric acid, 2.) aq. potassium iodide / 1.) 1 h, 2.) room temp., overnight

2: 46 percent / triphenylphosphine, palladium chloride, cuprous iodide, diethylamine / CH₂Cl₂ / 20 h / Ambient temperature

With copper(l) iodide; sulfuric acid; diethylamine; triphenylphosphine; potassium iodide; palladium dichloride; sodium nitrite; In dichloromethane;
DOI:10.1021/jo00133a040