3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

Base Information

Chemical Name:3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride
CAS No.:85721-00-2
Molecular Formula:C16H16Cl3N
Molecular Weight:328.669
Hs Code.:
European Community (EC) Number:288-409-2
DSSTox Substance ID:DTXSID701006325
ChEMBL ID:CHEMBL544266
Mol file:85721-00-2.mol

Synonyms:EINECS 288-409-2;3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride;Indatralin;85721-00-2;CHEMBL544266;(1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-aminehydrochloride;C16H15Cl2N.ClH;SCHEMBL5436564;C16-H15-Cl2-N.Cl-H;DTXSID701006325;3-(3,4-Dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine--hydrogen chloride (1/1);rel-(1R,3S)-3-(3,4-Dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride;rel-(1R,3S)-3-(3,4-Dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-aminehydrochloride

Suppliers and Price of 3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

Chemical Property:

Vapor Pressure:1.49E-06mmHg at 25°C
Boiling Point:398.3°Cat760mmHg
Flash Point:194.7°C
PSA：12.03000
Density:g/cm³
LogP:5.98240
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:327.034833
Heavy Atom Count:20
Complexity:309

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNC1CC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl

Technology Process of 3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

There total 5 articles about 3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.8%

: 748724-48-3,86939-10-8
LNK 131

: 85721-00-2,96850-13-4
C₁₆H₁₅Cl₂N*ClH

Guidance literature:: With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 1h;

Reference yield: 10.8%

: 85662-98-2,80272-27-1
3-(3',4'-dichlorophenyl)-indan-1-one

: 74-89-5
methylamine

: 85721-00-2,96850-13-4
C₁₆H₁₅Cl₂N*ClH

Guidance literature:: 3-(3',4'-dichlorophenyl)-indan-1-one; methylamine; With titanium isopropoxide; methanol; sodium cyanotrihydridoborate; at 40 ℃;

With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.1c01845

Reference yield:

: 95-50-1
1,2-dichloro-benzene

: 85721-00-2,96850-13-4
C₁₆H₁₅Cl₂N*ClH

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: titanium(IV) isopropylate; sodium cyanoborohydride / methanol / 40 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; aluminum (III) chloride; sodium cyanoborohydride; In methanol; diethyl ether; dichloromethane;