1-[(Trimethylsilyl)methyl]pyrrolidin-2-one

Base Information

• Chemical Name: 1-[(Trimethylsilyl)methyl]pyrrolidin-2-one
• CAS No.: 76596-19-5
• Molecular Formula: C8H17NOSi
• Molecular Weight: 171.315
• DSSTox Substance ID: DTXSID50519096
• Wikidata: Q82382045

Synonyms:76596-19-5;1-[(Trimethylsilyl)methyl]pyrrolidin-2-one;2-Pyrrolidinone, 1-[(trimethylsilyl)methyl]-;1-((Trimethylsilyl)methyl)pyrrolidin-2-one;N-trimethylsilylmethyl-2-pyrrolidone;1-(trimethylsilylmethyl)pyrrolidin-2-one;DTXSID50519096

Chemical Property of 1-[(Trimethylsilyl)methyl]pyrrolidin-2-one

Chemical Property:

• PSA: 20.31000
• LogP: 1.84240
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 171.107940700
• Heavy Atom Count: 11
• Complexity: 162

Purity/Quality:

99% ^*data from raw suppliers

1-[(trimethylsilyl)methyl]-2-Pyrrolidinone 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)CN1CCCC1=O

Technology Process of 1-[(Trimethylsilyl)methyl]pyrrolidin-2-one

There total 3 articles about 1-[(Trimethylsilyl)methyl]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Trifluoro-methanesulfonate5-methoxy-1-trimethylsilanylmethyl-3,4-dihydro-2H-pyrrolium; (76596-18-4) → 1-<(trimethylsilyl)methyl>-2-pyrrolidinone (76596-19-5)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/ja00547a056

Reference yield:

2-pyrrolidinon (616-45-5) + iodo(trimethylsilyl)methane (4206-67-1) → 1-<(trimethylsilyl)methyl>-2-pyrrolidinone (76596-19-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) Me₂SO, 20 deg C, 90 min 2.) RT, overnight;

DOI:10.1021/jo00212a034

Reference yield:

2-pyrrolidinon (616-45-5) + Chloromethyltrimethylsilane (2344-80-1) → 1-<(trimethylsilyl)methyl>-2-pyrrolidinone (76596-19-5)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1) DMSO, benzene, reflux, 8 h, 2) DMSO, benzene, RT, 1 d;

upstream raw materials:

2-pyrrolidinon

iodo(trimethylsilyl)methane

Chloromethyltrimethylsilane

Trifluoro-methanesulfonate5-methoxy-1-trimethylsilanylmethyl-3,4-dihydro-2H-pyrrolium;

Downstream raw materials:

3-<(o-Nitrobenzyl)oxy>-1-<(trimethylsilyl)methyl>-2-pyrrolidinone

3-Benzyloxy-1-trimethylsilanylmethyl-pyrrolidin-2-one

Trifluoro-methanesulfonate4-benzyloxy-5-methoxy-1-trimethylsilanylmethyl-3,4-dihydro-2H-pyrrolium;

1-methyl-pyrrolidin-2-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 76596-19-5 2-Pyrrolidinone, 1-[(trimethylsilyl)methyl]-

Send

Send

Metric Ton KG G Pound L ML

Send

Send