2-Benzoxazolemethanol

Base Information

• Chemical Name: 2-Benzoxazolemethanol
• CAS No.: 77186-95-9
• Molecular Formula: C8H7NO2
• Molecular Weight: 149.14700
• Hs Code.: 2934999090
• Mol file: 77186-95-9.mol

Synonyms:1,3-benzoxazol-2-ylmethanol;

Chemical Property of 2-Benzoxazolemethanol

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Boiling Point: 263.596oC at 760 mmHg
• PKA: 13.28±0.10(Predicted)
• Flash Point: 113.219oC
• PSA: 46.26000
• Density: 1.315g/cm3
• LogP: 1.32010
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Benzo[d]oxazol-2-ylmethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Benzoxazolemethanol

There total 2 articles about 2-Benzoxazolemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzo[d]oxazole-2-carbonyl chloride (408538-63-6) → 2-hydroxymethyl-benzoxazole (77186-95-9)

Guidance literature:

With diethyl ether; phenylmagnesium bromide;

Reference yield:

glycolic Acid (79-14-1) + 2-amino-phenol (95-55-6) → 2-hydroxymethyl-benzoxazole (77186-95-9)

Guidance literature:

Reference yield:

Togni's reagent (887144-97-0) + 2-hydroxymethyl-benzoxazole (77186-95-9) + N-benzoylethyleneimine (13313-25-2) → C18H15F3N2O3 + C18H15F3N2O3

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; C₃₇H₃₈N₂O₂; In N,N-dimethyl acetamide; at -20 ℃; for 72h; Overall yield = 55 percent; Overall yield = 40.1 mg; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.202008338

upstream raw materials:

benzo[d]oxazole-2-carbonyl chloride

glycolic Acid

2-amino-phenol