2-Chloro-3-ethoxy-quinoxaline

Base Information

• Chemical Name: 2-Chloro-3-ethoxy-quinoxaline
• CAS No.: 77768-09-3
• Molecular Formula: C10H9ClN2O
• Molecular Weight: 208.64
• Mol file: 77768-09-3.mol

Synonyms:

Chemical Property of 2-Chloro-3-ethoxy-quinoxaline

Chemical Property:

• Melting Point: 71-73℃
• Boiling Point: 287℃
• Flash Point: 127℃
• Density: 1.284
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-chloro-3-ethoxyquinoxaline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3-ethoxy-quinoxaline

There total 4 articles about 2-Chloro-3-ethoxy-quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,3-dichloroquinoxaline (2213-63-0) + ethanol (64-17-5) → 2-chloro-3-ethoxyquinoxaline (77768-09-3)

Guidance literature:

With sodium; at 20 ℃;

DOI:10.1002/anie.201913620

Reference yield:

2,3-dihydroxyquinoxaline (15804-19-0) → 2-chloro-3-ethoxyquinoxaline (77768-09-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1,2-dichloro-ethane; N,N-dimethyl-formamide / Reflux

2: sodium / 20 °C

With thionyl chloride; sodium; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/anie.201913620

Reference yield:

2,3-dichloroquinoxaline (2213-63-0) + sodium ethanolate (141-52-6) → 2-chloro-3-ethoxyquinoxaline (77768-09-3)

Guidance literature:

DOI:10.1039/jr9480000519

upstream raw materials:

2,3-dichloroquinoxaline

sodium ethanolate

ethanol

2,3-dihydroxyquinoxaline

Refernces

• 1、 Keivanloo, Ali,Soozani, Atena,Bakherad, Mohammad,Mirzaee, Mahdi,Rudbari, Hadi Amiri,Bruno, Giuseppe. "Development of an unexpected reaction pathway for the synthesis of 1,2,4-trisubstituted pyrrolo[1,2-a]quinoxalines through palladium-catalyzed cascade reactions". . p. 1633 - 1639. Retrieved 2017/03/08.
• 2、 -. "AROMATIC NITROGEN-CONTAINING 6-MEMBERED RING COMPOUNDS AND THEIR USE". Page/Page column 60. . Retrieved 2010/04/06.