1-(1-Phenylcyclohexyl)-4-hydroxypiperidine

Base Information

Chemical Name:1-(1-Phenylcyclohexyl)-4-hydroxypiperidine
CAS No.:60232-85-1
Molecular Formula:C17H25 N O
Molecular Weight:259.392
Hs Code.:
NSC Number:170516
UNII:AE1041687F
DSSTox Substance ID:DTXSID10208979
Nikkaji Number:J390.372I
Wikidata:Q6120311
ChEMBL ID:CHEMBL422629
Mol file:60232-85-1.mol

Synonyms:1-(1-phenylcyclohexyl)-4-hydroxypiperidine;PCHP

Suppliers and Price of 1-(1-Phenylcyclohexyl)-4-hydroxypiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
1-(1-Phenylcyclohexyl)-4-hydroxypiperidine ≥98%
1mg
$ 141.00

American Custom Chemicals Corporation
1-(1-PHENYLCYCLOHEXYL)-4-HYDROXYPIPERIDINE 95.00%
5MG
$ 498.04

AK Scientific
1-(1-Phenylcyclohexyl)-4-hydroxypiperidine
1mg
$ 275.00

Total 28 raw suppliers

Chemical Property of 1-(1-Phenylcyclohexyl)-4-hydroxypiperidine

Chemical Property:

Vapor Pressure:3.79E-07mmHg at 25°C
Melting Point:116-118 °C(Solv: hexane (110-54-3); ethanol (64-17-5))
Boiling Point:400.9°C at 760 mmHg
PKA:14.86±0.20(Predicted)
Flash Point:106.1°C
PSA：23.47000
Density:1.093g/cm³
LogP:3.24060
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:259.193614421
Heavy Atom Count:19
Complexity:271

Purity/Quality:

99% ^*data from raw suppliers

1-(1-Phenylcyclohexyl)-4-hydroxypiperidine ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(CC1)(C2=CC=CC=C2)N3CCC(CC3)O
Uses 4-Hydroxy Phencyclidine is a major monohydroxy metabolite of Phencyclidine (P295502) that produces PCP-like stimuli.

Technology Process of 1-(1-Phenylcyclohexyl)-4-hydroxypiperidine

There total 10 articles about 1-(1-Phenylcyclohexyl)-4-hydroxypiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 60756-86-7
4-hydroxypiperidinocyclohexyl carbonitrile

: phenylmagnesium bromide

: 60232-85-1
1-(1-phenylcyclohexyl)-4-hydroxypiperidine

Guidance literature:: In tetrahydrofuran; 1.) reflux, 2 h, 2.) 22 deg C;

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 60756-86-7
4-hydroxypiperidinocyclohexyl carbonitrile

: 106-93-4
ethylene dibromide

: 60232-85-1
1-(1-phenylcyclohexyl)-4-hydroxypiperidine

Guidance literature:: With ammonium chloride; iodine; magnesium; In tetrahydrofuran; methanol; chloroform;

Reference yield:

: 77-10-1
Phencyclidine

: 60232-85-1
1-(1-phenylcyclohexyl)-4-hydroxypiperidine

: 60756-83-4
4-Phenyl-4-piperidinocyclohexanol

: 77160-83-9
5-pentanoic acid

: 94852-59-2
3-hydroxy-1-(1-phenylcyclohexyl)piperidine

Guidance literature:: With oxygen; ethylene diamine tetraacetic acid tetrasodium salt; iron(II) sulfate; isoascorbic acid; In water; at 37 ℃; for 1h; Yield given. Further byproducts given; sodium phosphate buffer; var. reag.: Fe(III)TPPCl with iodosylxylene, or cumenehydroperoxide or O₂/Zn/AcOH;
DOI:10.1248/cpb.37.1788