Benzene, 1,2-dimethoxy-4-(phenylmethyl)-

Base Information

• Chemical Name: Benzene, 1,2-dimethoxy-4-(phenylmethyl)-
• CAS No.: 78238-97-8
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• DSSTox Substance ID: DTXSID00440780
• Nikkaji Number: J905.937G
• Wikidata: Q82257183
• Mol file: 78238-97-8.mol

Synonyms:Benzene, 1,2-dimethoxy-4-(phenylmethyl)-;78238-97-8;SCHEMBL83495;1,2-Dimethoxy-4-benzylbenzene;DTXSID00440780

Chemical Property of Benzene, 1,2-dimethoxy-4-(phenylmethyl)-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 228.115029749
• Heavy Atom Count: 17
• Complexity: 211

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CC2=CC=CC=C2)OC

Technology Process of Benzene, 1,2-dimethoxy-4-(phenylmethyl)-

There total 21 articles about Benzene, 1,2-dimethoxy-4-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate (260783-80-0) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → (3,4-dimethoxyphenyl)phenylmethane (78238-97-8)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium phosphate; cyclohexyldiphenylphosphine; In 1,4-dioxane; at 40 ℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox;

DOI:10.1021/ja3089422

Reference yield: 99.0%

benzyl bromide (100-39-0) + 3,4-Dimethoxyphenylboronic acid (122775-35-3) → (3,4-dimethoxyphenyl)phenylmethane (78238-97-8)

Guidance literature:

With [(1,7-bis{(pyridin-2′-yl)hydroxymethyl}-1,7-dicarba-closo-dodecaborane(-1H))PdCl]*DMF; potassium carbonate; In water; at 110 ℃; for 10h; Reagent/catalyst;

DOI:10.1021/ic5013999

Reference yield: 93.0%

phenyl benzyl ketone (451-40-1) + 4-Bromoveratrole (2859-78-1) → (3,4-dimethoxyphenyl)phenylmethane (78238-97-8)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; palladium dichloride; In water; at 130 - 160 ℃; for 1h; Microwave irradiation;

DOI:10.1021/ol900874z

upstream raw materials:

3,4-dimethoxybenzophenone

1,2-dimethoxybenzene

benzyl chloride

benzyl alcohol

Downstream raw materials:

(2-bromo-4,5-dimethoxyphenyl)phenylmethane

2-benzyl-3-bromo-5,6-dimethoxyphenyl acetate

4-benzyl-pyrocatechol

2-benzyl-3-bromo-5,6-dimethoxyphenol