(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid

Base Information

Chemical Name:(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid
CAS No.:73724-43-3
Molecular Formula:C22H25NO4S2
Molecular Weight:431.577
Hs Code.:2930 90 16
European Community (EC) Number:277-574-6
DSSTox Substance ID:DTXSID90224036
Nikkaji Number:J295.252A
Wikidata:Q72478931
Mol file:73724-43-3.mol

Synonyms:73724-43-3;Fmoc-Cys(StBu)-OH;(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid;N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-S-(tert-butylthio)-L-cysteine;(2R)-3-(tert-butyldisulfanyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid;3-((1,1-Dimethylethyl)dithio)-N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-alanine;Fmoc-L-Cys(StBu)-OH;C22H25NO4S2;MFCD00042617;Fmoc-S-tert-butylthio-L-cysteine;EINECS 277-574-6;Fmoc-Cys(S-tBu);N-Fmoc-S-tert-butylthiol-L-cysteine;Fmoc-Cys(tBuS)-OH;Fmoc-Cys(StBu)--OH;SCHEMBL1739174;DTXSID90224036;AKOS016014153;FD21273;HY-W023145;Nalpha-Fmoc-S-tert-butylthio-L-cysteine;AS-74259;PD197070;CS-0059648;Fmoc-Cys(StBu)-OH, >=95.0% (HPLC);NS00037550;A837910;N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-(t-butylthio)-L-cysteine;(2R)-3-(tert-butyldisulfanyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid;(r)-2-((((9h-fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyl disulfanyl)propanoic acid

Suppliers and Price of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoicAcid
100mg
$ 45.00

TRC
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoicAcid
500mg
$ 65.00

Sigma-Aldrich
Fmoc-Cys(tButhio)-OH Novabiochem?
25 g
$ 538.00

Sigma-Aldrich
Fmoc-Cys(tButhio)-OH Novabiochem . CAS 73724-43-3, molar mass 431.57 g/mol., Novabiochem
8520220025
$ 520.00

Sigma-Aldrich
Fmoc-Cys(StBu)-OH ≥95.0% (HPLC)
1g
$ 61.50

Iris Biotech GmbH
Fmoc-L-Cys(StBu)-OH
5 g
$ 168.75

Iris Biotech GmbH
Fmoc-L-Cys(StBu)-OH
25 g
$ 675.00

Crysdot
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoicacid 95+%
10g
$ 265.00

Chem-Impex
Fmoc---butylthio-L-cysteine ≥ 99.5% (Chiral HPLC)
100G
$ 1650.00

Chem-Impex
Fmoc-S-tert-butylthio-L-cysteine,99.5%(ChiralHPLC) 99.5%(ChiralHPLC)
5G
$ 106.40

Total 62 raw suppliers

Chemical Property of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid

Chemical Property:

Appearance/Colour:White powder
Vapor Pressure:2.21E-16mmHg at 25°C
Melting Point:73-77 °C
Refractive Index:1.62
Boiling Point:623 °C at 760 mmHg
PKA:3.39±0.10(Predicted)
Flash Point:330.6 °C
PSA：126.23000
Density:1.281 g/cm³
LogP:5.54910
Storage Temp.:2-8°C
XLogP3:4.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:431.12250063
Heavy Atom Count:29
Complexity:558

Purity/Quality:

99%, ^*data from raw suppliers

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)SSCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Isomeric SMILES:CC(C)(C)SSC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Technology Process of (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid

There total 4 articles about (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butyldisulfanyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 135248-89-4
N^α-fluoren-9-ylmethoxycarbonyl-L-cysteine

: 75-66-1
2-methylpropan-2-thiol

: 73724-43-3
3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Guidance literature:: With ammonium acetate; dimethyl sulfoxide; In water; acetonitrile; at 150 ℃; for 0.0833333h; Microwave irradiation;
DOI:10.1021/jo902695a

Reference yield: 84.0%

: 30044-51-0
S-tert-butylmercapto-L-cysteine

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 73724-43-3
3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Guidance literature:: With sodium hydroxide; sodium carbonate; In 1,4-dioxane; water; 1.) ice bath, 2 h, 2.) room temp., 15 min;

Reference yield:

: 135273-01-7
N,N'-bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-cystine

: 73724-43-3
3-[(1,1-dimethylethyl)dithio]-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; hydrogenchloride / water; ethyl acetate

2: 5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine / dichloromethane / 2 h / Neutral conditions

With hydrogenchloride; 5,5'-dinitro-2,2'-disulfanediyl-bis-pyridine; zinc; In dichloromethane; water; ethyl acetate;