N-Methoxy-N-MethylcyclohexanecarboxaMide

Base Information

• Chemical Name: N-Methoxy-N-MethylcyclohexanecarboxaMide
• CAS No.: 80783-98-8
• Molecular Formula: C9H17NO2
• Molecular Weight: 171.239
• Hs Code.: 2924299090
• Mol file: 80783-98-8.mol

Synonyms:Cyclohexanecarboxamide,N-methoxy-N-methyl;cyclohexyl-N-methyl-N-methoxycarboxamide;cyclohexanecarboxylic acid methoxy(methyl)amide;N-methyl-N-methoxycyclohexylcarbonamide;N-methoxy-N-methyl cyclohexyl amide;N-Methyl-N-methoxy-cyclohexanecarboxamide;

Chemical Property of N-Methoxy-N-MethylcyclohexanecarboxaMide

Chemical Property:

• Boiling Point: 223.1±23.0 °C(Predicted)
• PSA: 29.54000
• Density: 1.020±0.06 g/cm3(Predicted)
• LogP: 1.58650

Purity/Quality:

99.90% ^*data from raw suppliers

N-methoxy-N-methylcyclohexanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methoxy-N-MethylcyclohexanecarboxaMide

There total 13 articles about N-Methoxy-N-MethylcyclohexanecarboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Cyclohexanecarboxylic acid (98-89-5) → N-methoxy-N-methylcyclohexanecarboxamide (80783-98-8)

Guidance literature:

Cyclohexanecarboxylic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/acs.orglett.8b02435

Reference yield: 99.0%

methyl cyclohexylcarboxylate (4630-82-4) + N,0-dimethylhydroxylamine (1117-97-1) → N-methoxy-N-methylcyclohexanecarboxamide (80783-98-8)

Guidance literature:

With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 20 ℃; for 10h; Inert atmosphere;

DOI:10.1002/anie.201702826

Reference yield: 97.0%

N,0-dimethylhydroxylamine (1117-97-1) + Cyclohexanecarboxylic acid (98-89-5) → N-methoxy-N-methylcyclohexanecarboxamide (80783-98-8)

Guidance literature:

N,0-dimethylhydroxylamine; Cyclohexanecarboxylic acid; In toluene; at 0 ℃; for 0.166667h;

With phosphorus trichloride; In toluene; at 20 - 60 ℃; for 0.5h;

DOI:10.1055/s-0033-1340317

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

cyclohexanylcarbonyl chloride

methyl cyclohexylcarboxylate

N,0-dimethylhydroxylamine

Downstream raw materials:

Cyclohexyl phenyl ketone

cyclohexanecarbaldehyde

α-deuterio-cyclohexanecarboxaldehyde

(4-chlorophenyl)(cyclohexyl)methanone

Refernces

• 1、 Bauer, Adriano,Di Mauro, Giovanni,Li, Jing,Maulide, Nuno. "An α-Cyclopropanation of Carbonyl Derivatives by Oxidative Umpolung". supporting information. p. 18208 - 18212. Retrieved 2020/08/21.
• 2、 Zygalski, Lukas,Middel, Christoph,Harms, Klaus,Koert, Ulrich. "Enolizable β-Fluoroenones: Synthesis and Asymmetric 1,2-Reduction". supporting information. p. 5071 - 5074. Retrieved 2018/08/24.