2'-Hydroxy-4,4',5',6'-tetramethoxychalcone

Base Information

Chemical Name:2'-Hydroxy-4,4',5',6'-tetramethoxychalcone
CAS No.:3877-67-6
Molecular Formula:C19H20O6
Molecular Weight:344.364
Hs Code.:2914509090
NSC Number:271637
DSSTox Substance ID:DTXSID50422258
Nikkaji Number:J1.571.589H,J19.058F
Wikidata:Q76323893
Metabolomics Workbench ID:26820
ChEMBL ID:CHEMBL2208193
Mol file:3877-67-6.mol

Synonyms:2'-hydroxy-4,4',5',6'-tetramethoxychalcone;3877-67-6;(E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one;NSC271637;CHEMBL2208193;6'-Hydroxy-4,2',3',4'-tetramethoxychalcone;41929-26-4;Odoratin[Eupatorium];Odoratin (Eupatorium);SCHEMBL738714;DTXSID50422258;FRISOFZUHCOQEC-JXMROGBWSA-N;FLAVONE B646854K031;BDBM50403019;LMPK12120345;NSC-271637;1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one;(E)-1-(6-Hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one;2-Propen-1-one, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)-, (2E)-;2-Propen-1-one, 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)-, (E)-

Suppliers and Price of 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone

Chemical Property:

Vapor Pressure:4.43E-13mmHg at 25°C
Boiling Point:558.5°Cat760mmHg
Flash Point:200.2°C
PSA：74.22000
Density:1.211g/cm³
LogP:3.32270
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:344.12598835
Heavy Atom Count:25
Complexity:443

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C=CC(=O)C2=C(C(=C(C=C2O)OC)OC)OC
Isomeric SMILES:COC1=CC=C(C=C1)/C=C/C(=O)C2=C(C(=C(C=C2O)OC)OC)OC

Technology Process of 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone

There total 5 articles about 2'-Hydroxy-4,4',5',6'-tetramethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 22248-14-2
6-hydroxy-2,3,4-trimethoxyacetophenone

: 123-11-5
4-methoxy-benzaldehyde

: 3877-67-6
1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃; for 50h; Reagent/catalyst;
DOI:10.3184/174751913X13813183192507

Reference yield:

: 642-71-7
3,4,5-trimethoxyphenol

: 3877-67-6
1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 2 h / 75 °C

2: potassium hydroxide / methanol / 50 h / 20 °C

With boron trifluoride diethyl etherate; potassium hydroxide; In methanol; 1: |Fries Phenol Ester Rearrangement / 2: |Claisen-Schmidt Condensation;
DOI:10.3184/174751913X13813183192507