2-(2-Aminophenyl)propan-2-ol

Base Information

• Chemical Name: 2-(2-Aminophenyl)propan-2-ol
• CAS No.: 15833-00-8
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 2922199090
• NSC Number: 76547
• DSSTox Substance ID: DTXSID40291576
• Wikidata: Q72440835
• Mol file: 15833-00-8.mol

Synonyms:2-(2-aminophenyl)propan-2-ol;15833-00-8;2-(2-Aminophenyl)-2-propanol;2-(2-Hydroxypropan-2-yl)aniline;NSC76547;benzenemethanol, 2-amino-alpha,alpha-dimethyl-;o-aminophenyldimethylcarbinol;SCHEMBL79300;o-aminophenyl-dimethylcarbinol;2-aminophenyldimethyl carbinol;DTXSID40291576;2-(2-amino-phenyl)-propan-2-ol;MFCD04117984;NSC-76547;AKOS005174024;DS-4735;SB76073;alpha,alpha-dimethyl-2-aminobenzyl alcohol;BB 0257335;CS-0154621;FT-0683774;C72989;2-AMINO-ALPHA,ALPHA-DIMETHYLBENZYL ALCOHOL

Chemical Property of 2-(2-Aminophenyl)propan-2-ol

Chemical Property:

• Vapor Pressure: 0.00104mmHg at 25°C
• Refractive Index: 1.57
• Boiling Point: 289.1 °C at 760 mmHg
• PKA: 14.35±0.29(Predicted)
• Flash Point: 128.7 °C
• PSA: 46.25000
• Density: 1.084 g/cm³
• LogP: 2.07740
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

97% ^*data from raw suppliers

2-(2-Aminophenyl)propan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC=CC=C1N)O

Technology Process of 2-(2-Aminophenyl)propan-2-ol

There total 12 articles about 2-(2-Aminophenyl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methylmagnesium bromide (75-16-1) + 2-carbomethoxyaniline (134-20-3) → o-aminophenyldimethylcarbinol (15833-00-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tet.2006.10.030

Reference yield: 90.0%

methyl magnesium iodide (917-64-6) + 2-aminoacetophenone (551-93-9) → o-aminophenyldimethylcarbinol (15833-00-8)

Guidance literature:

In diethyl ether; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2011.06.001

Reference yield: 81.0%

methylmagnesium bromide (75-16-1) + 2-aminoacetophenone (551-93-9) → o-aminophenyldimethylcarbinol (15833-00-8)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 5h; Inert atmosphere;

upstream raw materials:

methyl magnesium iodide

2-ethoxycarbonylaniline

2-carbomethoxyaniline

methylmagnesium bromide

Downstream raw materials:

2-isopropenylaniline

4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazine-2-thione

1,4-Dihydro-4,4-dimethyl-1,3-benzo[d]oxazin-2-one

6-Amino-1,4-dihydro-4,4-dimethyl-1,3-benzo[d]oxazin-2-one