1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)amino]-, methyl ester

Base Information

Chemical Name:1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)amino]-, methyl ester
CAS No.:825619-05-4
Molecular Formula:C12H9Cl2N3O3
Molecular Weight:314.128
Hs Code.:

Synonyms:4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxylic acid methyl ester;

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Chemical Property of 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)amino]-, methyl ester

Chemical Property:

PSA：84.08000
LogP:2.82840

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)amino]-, methyl ester

There total 2 articles about 1H-Pyrazole-3-carboxylic acid, 4-[(2,6-dichlorobenzoyl)amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4659-45-4
2,6-Dichlorobenzoyl chloride

: 360056-45-7
methyl 4-amino-1H-pyrazole-3-carboxylate

: 825619-05-4
methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate

Guidance literature:: With triethylamine; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

: 138786-86-4,1345513-95-2
methyl 4-nitro-1H-pyrazole-3-carboxylate

: 825619-05-4
methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium formate; 5%-palladium/activated carbon / tetrahydrofuran; isopropyl alcohol; water / 1 h / Reflux

2: triethylamine / 1,4-dioxane / 12 h / 0 °C

With 5%-palladium/activated carbon; ammonium formate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; isopropyl alcohol;
DOI:10.1016/j.ejmech.2020.112073

Reference yield: 99.5%

: 825619-05-4
methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate

: 825619-04-3
4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylic acid

Guidance literature:: methyl 4-(2,6-dichlorobenzamido)-1H-pyrazole-3-carboxylate; With sodium hydroxide; water; at 20 - 25 ℃;

With hydrogenchloride; In water; at 30 ℃; pH=1; Product distribution / selectivity;