S-(+)-Etomoxir

Base Information

Chemical Name:S-(+)-Etomoxir
CAS No.:828934-40-3
Molecular Formula:C₁₇H₂₃ClO₄
Molecular Weight:326.82
Hs Code.:
Mol file:828934-40-3.mol

Synonyms:S-(-)-Etomoxir;S-(+)-Etomoxir;Oxiranecarboxylic acid, 2-[6-(4-chlorophenoxy)hexyl]-, ethyl ester, (2S)-;

Suppliers and Price of S-(+)-Etomoxir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
S-(-)-Etomoxir
100mg
$ 1230.00

TRC
S-(-)-Etomoxir
10mg
$ 155.00

Total 3 raw suppliers

Chemical Property of S-(+)-Etomoxir

Chemical Property:

PSA：48.06000
LogP:4.00140

Purity/Quality:

97% ^*data from raw suppliers

S-(-)-Etomoxir ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of S-(+)-Etomoxir

There total 33 articles about S-(+)-Etomoxir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 106-48-9,82344-39-6
4-chloro-phenol

: 191412-56-3
(R)-2-(6-Hydroxy-hexyl)-oxirane-2-carboxylic acid ethyl ester

: 124083-20-1,828934-40-3
(R)-(+)-etomoxir

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1016/S0957-4166(97)00105-5

Reference yield:

: 82258-37-5
ethyl 2-[6-(p-chlorophenoxy)hexyl]acrylate

: 124083-20-1,828934-40-3
(R)-(+)-etomoxir

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NMO; water; OsO₄ / toluene; 2-methyl-propan-2-ol / 1 h / 20 °C

2: 44 percent / Amano AK / various solvent(s) / 2 h / 20 °C / Enzymatic reaction

3: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4: potassium carbonate / ethanol / 6 h / 20 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; Amano AK; water; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; toluene; tert-butyl alcohol; 1: dihydroxylation / 2: kinetic resolution / 3: mesylation / 4: Cyclization;
DOI:10.1016/S0957-4166(00)00304-9

Reference yield:

: 124083-16-5
8-(4-Chloro-phenoxy)-2-methylene-octanoyl chloride

: 124083-20-1,828934-40-3
(R)-(+)-etomoxir

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / NaBH₄-silica / diethyl ether / 18 h / Ambient temperature

2: 49 percent / t-butylhydroperoxide, titanium isopropoxide, diethyl L-(+)-tartrate / -20 deg C, 3 h. then room temp., 1 h.

3: 1.) NaIO₄; 2.) NaHCO₃ / 1.) RuCl₃ / 1.) CCl₄, CH₃CN, H₂O, room temp., 7 h.; 2.) DMF, room temp.

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium tetrahydroborate; sodium periodate; diethyl (2R,3R)-tartrate; silica gel; sodium hydrogencarbonate; ruthenium trichloride; In diethyl ether;
DOI:10.1016/S0040-4039(01)80643-2