isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester

Base Information

Chemical Name:isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester
CAS No.:128923-36-4
Molecular Formula:C₃₀H₅₀N₃O₈P
Molecular Weight:611.716
Hs Code.:
Mol file:128923-36-4.mol

Synonyms:L-Valinamide,N-(3-methyl-1-oxobutyl)-L-valyl-N-[1-[hydroxy[2-methoxy-2-oxo-1-(phenylmethyl)ethoxy]phosphinyl]-3-methylbutyl]-,[R-(R*,S*)]-

Suppliers and Price of isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
PSA：176.92000
Density:1.137g/cm³
LogP:5.86030

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester

There total 10 articles about isovaleryl-valyl-valyl-leucine phosphinate-3-phenyllactic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128948-77-6
<(1R)-1-amino>-3-methylbutyl>phosphonic acid

: 128923-36-4
Iva-Val-Val-Leu^P-(O)Phe-OMe

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / 9 h / 110 °C

2: 95 percent / 2 N NaOH / methanol / 12 h / 21 °C

3: SOCl₂ / CH₂Cl₂ / 4 h

4: Et₃N / CH₂Cl₂

5: H₂ / 10percent Pd/C / ethyl acetate

6: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.

7: 1) isobutylene, trimethylsilylbromide, 2) methanol / 1) CH₂Cl₂, r.t.

With 4-methyl-morpholine; methanol; sodium hydroxide; thionyl chloride; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012

Reference yield:

: 128948-78-7
methyl hydrogen ((1R)-1-{N-[(phenylmethoxy)carbonyl]amino}-3-methylbutyl)phosphonate

: 128923-36-4
Iva-Val-Val-Leu^P-(O)Phe-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / CH₂Cl₂ / 4 h

2: Et₃N / CH₂Cl₂

3: H₂ / 10percent Pd/C / ethyl acetate

4: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.

5: 1) isobutylene, trimethylsilylbromide, 2) methanol / 1) CH₂Cl₂, r.t.

With 4-methyl-morpholine; methanol; thionyl chloride; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012

Reference yield:

: 90763-55-6
C₁₄H₂₁ClNO₄P

: 128923-36-4
Iva-Val-Val-Leu^P-(O)Phe-OMe

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂

2: H₂ / 10percent Pd/C / ethyl acetate

3: 1) N-methylmorpholine, isobutyl chloroformate / 1) EtOAc, -10 deg C, 2a) -10 deg C, 2b) r.t.

4: 1) isobutylene, trimethylsilylbromide, 2) methanol / 1) CH₂Cl₂, r.t.

With 4-methyl-morpholine; methanol; trimethylsilyl bromide; hydrogen; triethylamine; isobutene; isobutyl chloroformate; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo00313a012