4,4'-BIS(DIMETHYLAMINO)BENZIL

Base Information

• Chemical Name: 4,4'-BIS(DIMETHYLAMINO)BENZIL
• CAS No.: 17078-27-2
• Molecular Formula: C18H20 N2 O2
• Molecular Weight: 296.369
• Hs Code.: 29163990
• Mol file: 17078-27-2.mol

Synonyms:Benzil,4,4'-bis(dimethylamino)- (7CI,8CI); Ethanedione, bis[4-(dimethylamino)phenyl]-(9CI); 1,2-Bis[4-(dimethylamino)phenyl]ethane-1,2-dione;4,4'-Bis(dimethylamino)benzil; NSC 9030

Chemical Property of 4,4'-BIS(DIMETHYLAMINO)BENZIL

Chemical Property:

• Melting Point: 200-204 °C
• Refractive Index: 1.5700 (estimate)
• Boiling Point: 470.6°Cat760mmHg
• PKA: -0.17±0.12(Predicted)
• Flash Point: 206.7°C
• PSA: 40.62000
• Density: 1.156g/cm³
• LogP: 2.88420
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

4,4''-bis(Dimethylamino)benzil ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-36-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-BIS(DIMETHYLAMINO)BENZIL

There total 12 articles about 4,4'-BIS(DIMETHYLAMINO)BENZIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,2-bis[4-(dimethylamino)phenyl]-1,2-ethanediol (54322-62-2) → 4,4'-bis(dimethylamino)benzil (17078-27-2)

Guidance literature:

With ruthenium trichloride; bromamine T; In water; acetonitrile; at 80 ℃; for 0.2h; pH=8.4;

DOI:10.1081/SCC-200048974

Reference yield: 91.0%

bis(4-dimethylaminophenyl)ethyne (62063-67-6) → 4,4'-bis(dimethylamino)benzil (17078-27-2)

Guidance literature:

With ammonium iodide; potassium ethyl xanthogenate; In water; dimethyl sulfoxide; at 130 ℃; for 12h; chemoselective reaction; Schlenk technique;

DOI:10.1016/j.tetlet.2018.06.053

Reference yield: 69.0%

N,N-dimethyl-p-(dimethylamino)benzamide (21566-11-0) → 4,4'-bis(dimethylamino)benzil (17078-27-2)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; at 0 ℃; for 1h; Sonication;

DOI:10.1016/j.tet.2010.09.037

upstream raw materials:

oxalyl dichloride

N,N-dimethyl-aniline

4-dimethylaminophenyllithium

1,4-dimethyl-2,3-dioxopiperazine

Downstream raw materials:

7-hydroxy-2,3-bis(4-dimethylaminophenyl)-6-quinoxalinecarboxylic acid

2,3-bis-(4-dimethylaminophenyl)-5-quinoxalinecarboxylic acid

4,5-bis<4-(N,N-dimethylamino)phenyl>-1H-imidazole-2-thione

C₂₃H₂₄N₄S

Refernces

• 1、 Haddad, Batool Saleh,Al-Shawi, Ali A.A.. "Cytotoxicity of new selenoimine, selenonitrone, and nitrone derivatives against human breast cancer MDA-MB231 cells". . p. 4607 - 4613. Retrieved 2020/12/11.
• 2、 Jiang, Shaohua,Li, Yibiao,Luo, Xianglin,Huang, Guoling,Shao, Yan,Li, Dongli,Li, Bin. "NH4I/EtOCS2K promoted synthesis of substituted benzils from diphenylacetylene derivatives". supporting information. p. 3249 - 3252. Retrieved 2018/07/21.