Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate

Base Information

• Chemical Name: Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate
• CAS No.: 168127-29-5
• Molecular Formula: C₁₃H₁₄N₂O₃S
• Molecular Weight: 278.332
• DSSTox Substance ID: DTXSID40168491
• Wikidata: Q83038098
• Mol file: 168127-29-5.mol

Synonyms:Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate;168127-29-5;ethyl 2-[4-(2-amino-1,3-thiazol-4-yl)phenoxy]acetate;Acetic acid, (4-(2-amino-4-thiazolyl)phenoxy)-, ethyl ester;DTXSID40168491

Chemical Property of Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate

Chemical Property:

• Vapor Pressure: 1.05E-08mmHg at 25°C
• Boiling Point: 461.6°Cat760mmHg
• Flash Point: 233°C
• PSA: 102.68000
• Density: 1.284g/cm³
• LogP: 2.91540
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 278.07251349
• Heavy Atom Count: 19
• Complexity: 296

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=C(C=C1)C2=CSC(=N2)N

Technology Process of Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate

There total 3 articles about Ethyl (4-(2-amino-4-thiazolyl)phenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (4-acetylphenoxy)-acetate (51828-69-4) → [4-(2-Amino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester (168127-29-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / acetonitrile / 3 h / Heating

2: ethanol / 6 h / Heating

In ethanol; acetonitrile;

Reference yield:

thiourea (17356-08-0) + ethyl 4-(2-tosyloxyacetyl)phenoxyacetate (754231-46-4) → [4-(2-Amino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester (168127-29-5)

Guidance literature:

In ethanol; for 6h; Yield given; Heating;

Reference yield:

ethyl 4-(bromoacetyl)phenoxyacetate (29936-82-1) + thiourea (17356-08-0) → [4-(2-Amino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester (168127-29-5)

Guidance literature:

In ethanol; for 3h; Yield given; Heating;

upstream raw materials:

ethyl 4-(bromoacetyl)phenoxyacetate

thiourea

ethyl 4-(2-tosyloxyacetyl)phenoxyacetate

ethyl (4-acetylphenoxy)-acetate

Downstream raw materials:

2-(4-(2-aminothiazol-4-yl)phenoxy)acetic acid