Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate

Base Information

Chemical Name:Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate
CAS No.:84863-77-4
Molecular Formula:C13H11ClO2S
Molecular Weight:266.748
Hs Code.:
DSSTox Substance ID:DTXSID30515718
Wikidata:Q82376759

Synonyms:84863-77-4;Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate;DTXSID30515718;HNMFGIZMIPAACH-UHFFFAOYSA-N;Methyl 5-p-chlorophenylthien-2-ylacetate

Suppliers and Price of Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:266.0168285
Heavy Atom Count:17
Complexity:264

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)CC1=CC=C(S1)C2=CC=C(C=C2)Cl

Technology Process of Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate

There total 8 articles about Methyl [5-(4-chlorophenyl)thiophen-2-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 67-56-1
methanol

: 24680-42-0
2-(5-(4-chlorophenyl)thiophen-2-yl)acetic acid

: 84863-77-4
[5-(4-Chloro-phenyl)-thiophen-2-yl]-acetic acid methyl ester

Guidance literature:: With sulfuric acid; Heating;
DOI:10.1016/j.bmc.2003.08.009

Reference yield:

: 24680-29-3
[5-(4-chloro-phenyl)-thiophen-2-yl]-methanol

: 84863-77-4
[5-(4-Chloro-phenyl)-thiophen-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: HMPA; thionyl chloride / tetrahydrofuran / 20 °C

2: 18-crown-6 / acetonitrile / 20 °C

3: KOH / ethanol; H₂O / Heating

4: 67 percent / H₂SO₄ / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; thionyl chloride; 18-crown-6 ether; sulfuric acid; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2003.08.009

Reference yield:

: 24680-30-6
2-Chloromethyl-5-(4-chloro-phenyl)-thiophene

: 84863-77-4
[5-(4-Chloro-phenyl)-thiophen-2-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 18-crown-6 / acetonitrile / 20 °C

2: KOH / ethanol; H₂O / Heating

3: 67 percent / H₂SO₄ / Heating

With potassium hydroxide; 18-crown-6 ether; sulfuric acid; In ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2003.08.009