2-(Piperidin-1-ylmethyl)pyridine

Base Information

• Chemical Name: 2-(Piperidin-1-ylmethyl)pyridine
• CAS No.: 71172-77-5
• Molecular Formula: C11H16N2
• Molecular Weight: 176.261
• European Community (EC) Number: 654-610-2
• NSC Number: 78460
• DSSTox Substance ID: DTXSID50291820
• Wikidata: Q82029882
• Mol file: 71172-77-5.mol

Synonyms:2-(piperidin-1-ylmethyl)pyridine;71172-77-5;2-[(piperidin-1-yl)methyl]pyridine;NSC78460;SCHEMBL3161186;1-(2-pyridinylmethyl)piperidine;DTXSID50291820;NSC-78460;AKOS024323059

Chemical Property of 2-(Piperidin-1-ylmethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.0175mmHg at 25°C
• Boiling Point: 254.2°Cat760mmHg
• Flash Point: 107.5°C
• PSA: 16.13000
• Density: 1.042g/cm³
• LogP: 2.00540
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 141

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(piperidin-1-ylmethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CC2=CC=CC=N2

Technology Process of 2-(Piperidin-1-ylmethyl)pyridine

There total 1 articles about 2-(Piperidin-1-ylmethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-((trimethylsilyl)methyl)piperidine (17877-17-7) + 2-(phenylsulfonyl)pyridine (24244-60-8) → 2-(piperidin-1-yl-methyl)pyridine (71172-77-5)

Guidance literature:

With Eosin Y; In methanol; acetonitrile; at 20 ℃; for 3h; Irradiation;

DOI:10.1002/chem.202102124

Reference yield: 64.0%

2-(piperidin-1-yl-methyl)pyridine (71172-77-5) + 1-bromo-4-tert-butylbenzene (3972-65-4) + carbon monoxide (201230-82-2) → C22H28N2O

Guidance literature:

With lithium hexamethyldisilazane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; nixantphos; In 1,4-dioxane; at 80 ℃; for 16h; under 760.051 Torr;

DOI:10.1039/d1sc02078a

Reference yield:

2-(piperidin-1-yl-methyl)pyridine (71172-77-5) + benzaldehyde (100-52-7) → 1-phenyl-2-(piperidin-1-yl)-2-(pyridin-2-yl)ethan-1-amine + 1-phenyl-2-(piperidin-1-yl)-2-(pyridin-2-yl)ethan-1-amine

Guidance literature:

benzaldehyde; With N,N,N',N'',N'''-pentamethyldiethylenetriamine; sodium hexamethyldisilazane; In di-isopropyl ether; at 25 ℃; for 0.166667h; Inert atmosphere; Glovebox;

2-(piperidin-1-yl-methyl)pyridine; In di-isopropyl ether; at 10 ℃; for 12h; Overall yield = 83 percent; Overall yield = 46.6 mg; diastereoselective reaction; Further stages; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b03287

upstream raw materials:

1-((trimethylsilyl)methyl)piperidine

2-(phenylsulfonyl)pyridine

Downstream raw materials:

2-[(1-piperidinyl)methyl]piperidine