Cyclohexane,1-(1,1-dimethylethyl)-4-methoxy-cis-

Base Information

• Chemical Name: Cyclohexane,1-(1,1-dimethylethyl)-4-methoxy-cis-
• CAS No.: 15875-99-7
• Molecular Formula: C11H22 O
• Molecular Weight: 170.295
• Hs Code.: 2909499000
• Mol file: 15875-99-7.mol

Synonyms:Ether,4-tert-butylcyclohexyl methyl, cis- (8CI); cis-4-tert-Butylcyclohexyl methylether

Chemical Property of Cyclohexane,1-(1,1-dimethylethyl)-4-methoxy-cis-

Chemical Property:

• Vapor Pressure: 0.757mmHg at 25°C
• Boiling Point: 190.3°C at 760 mmHg
• Flash Point: 60.6°C
• PSA: 9.23000
• Density: 0.85g/cm³
• LogP: 3.23770

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexane,1-(1,1-dimethylethyl)-4-methoxy-cis-

There total 9 articles about Cyclohexane,1-(1,1-dimethylethyl)-4-methoxy-cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-tercbutyl-cyclohexanone (98-53-3) + trimethyl orthoformate (149-73-5) → cis-4-tert-butylcyclohexanol methyl ether (15875-99-7)

Guidance literature:

With C₁₈H₄BCl₃F₈; hydrogen; In tetrahydrofuran; at 80 ℃; for 60h; under 15001.5 Torr;

DOI:10.1002/anie.201700231

Reference yield: 89.0%

C13H26O2 → cis-4-tert-butylcyclohexanol methyl ether (15875-99-7)

Guidance literature:

With C₁₈H₄BCl₃F₈; hydrogen; In tetrahydrofuran; at 80 ℃; for 48h; under 15001.5 Torr;

DOI:10.1002/anie.201700231

Reference yield:

4-tert-butyl-1,1-dimethoxy-cyclohexane (944-19-4) → trans-4-tert-butylcyclohexanol methyl ether (15876-31-0) + cis-4-tert-butylcyclohexanol methyl ether (15875-99-7)

Guidance literature:

With trimethylsilan; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 29 ℃; for 16h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)93263-6

upstream raw materials:

cis-4-tert-butyl-1-cyclohexanol

dimethyl sulfate

methyl iodide

iodomethane-d3

Downstream raw materials:

methanolate

4-tert-butylcylohexene

tert-butylcyclohexane

4-(t-butyl)-1-methoxy-N-(perfluorophenyl)cyclohexanecarboxamide

Refernces

• 1、 Booth, Harold,Dixon, J. Mark,Khedhair, Khedhair A.,Readshaw, Simon A.. "Experimental studies of the anomeric effect. Part III. Rotameric preferences about the exo-cyclic c2-x bond in equatorial and axial 2-methoxy-and 2-methylamino-tetrahydropyrans". . p. 1625 - 1652. Retrieved 2007/10/02.
• 2、 Haines, Alan H.,Shandiz, Mohammad Seyedi. "13C Nuclear Magnetic Resonance Spectra of Methoxycyclohexane Derivatives. Rotamer Populations about C-OMe Bonds as indicated by 13C Chemical Shifts of Methoxy- and Ring-carbons and 3JC,H Coupling Constants". . p. 1671 - 1678. Retrieved 2007/10/02.