1H-Indole, 7-bromo-3-methyl-

Base Information

• Chemical Name: 1H-Indole, 7-bromo-3-methyl-
• CAS No.: 86915-22-2
• Molecular Formula: C9H8BrN
• Molecular Weight: 210.073
• Hs Code.: 2933998090
• Mol file: 86915-22-2.mol

Synonyms:7-bromo-3-hydroxy-naphthalene-2-carboxylic acid 3-morpholin-4-yl-propylamide;7-bromo-3-methylindole;3-methyl-7-bromoindole;

Chemical Property of 1H-Indole, 7-bromo-3-methyl-

Chemical Property:

• PSA: 15.79000
• LogP: 3.23880
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Bromo-3-methyl-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 7-bromo-3-methyl-

There total 14 articles about 1H-Indole, 7-bromo-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 7-bromo-1H-indole (51417-51-7) → 7-bromo-3-methyl-1H-indole (86915-22-2)

Guidance literature:

With cobalt(II) tetrafluoroborate hexahydrate; tris(2-diphenylphosphinoethyl)phosphine; potassium carbonate; at 100 ℃; for 24h; Autoclave; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02462

Reference yield: 85.0%

7-bromo-1-(2,2-diethylbutanoyl)-3-methylindole (242805-94-3) → 7-bromo-3-methyl-1H-indole (86915-22-2)

Guidance literature:

With potassium tert-butylate; water; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/S0040-4020(99)00487-1

Reference yield: 63.0%

2-nitrophenyl bromide (577-19-5) + (E)-1-propenylmagnesium bromide (1730-25-2,13154-14-8,13154-15-9,14092-04-7) → 7-bromo-3-methyl-1H-indole (86915-22-2)

Guidance literature:

In tetrahydrofuran; at -45 - -40 ℃;

DOI:10.1021/jo0057396

upstream raw materials:

3,7-Dibromo-3-methyl-1,3-dihydro-indol-2-one

7-bromo-1-(2,2-diethylbutanoyl)-3-methylindole

2-nitrophenyl bromide

(E)-1-propenylmagnesium bromide

Downstream raw materials:

3-Methylindole

C₃₃H₂₇NP₂

C₁₆H₁₄BrN

C₃₀H₃₀BrNO₅