H-GLY-PHE-GLY-OH

Base Information

• Chemical Name: H-GLY-PHE-GLY-OH
• CAS No.: 14656-09-8
• Molecular Formula: C13H17N3O4
• Molecular Weight: 279.296
• Hs Code.: 2924299090
• Mol file: 14656-09-8.mol

Synonyms:GLYCYL-L-PHENYLALANYL-GLYCINE;H-GLY-PHE-GLY-OH

Chemical Property of H-GLY-PHE-GLY-OH

Chemical Property:

• Vapor Pressure: 2.45E-19mmHg at 25°C
• Boiling Point: 678.5°Cat760mmHg
• Flash Point: 364.1°C
• PSA: 121.52000
• Density: 1.296g/cm³
• LogP: 0.35550
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

H-Gly-Phe-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-GLY-PHE-GLY-OH

There total 6 articles about H-GLY-PHE-GLY-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.7%

Fmoc-gly-wang resin + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + N-Fmoc L-Phe (35661-40-6) → glycyl-L-phenylalanyl-glycine (14656-09-8)

Guidance literature:

Fmoc-gly-wang resin; With piperidine; In N,N-dimethyl-formamide; Wang resin

N-Fmoc L-Phe; With 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); diisopropylamine; ethyl cyanoglyoxylate-2-oxime; In N,N-dimethyl-formamide; for 0.75h; Wang resin

N-(fluoren-9-ylmethoxycarbonyl)glycine; Further stages;

DOI:10.1002/ejoc.201300340

Reference yield:

→ glycyl-L-phenylalanyl-glycine (14656-09-8)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01520a065 DOI:10.1021/ja01588a027

Reference yield:

2-chlorotrityl resin + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + N-Fmoc-β-alanine (35737-10-1) + N-Fmoc L-Phe (35661-40-6) → Glyβ-AlaGly (42538-54-5) + glycyl-L-phenylalanyl-glycine (14656-09-8)

Guidance literature:

2-chlorotrityl resin; N-Fmoc-β-alanine; N-Fmoc L-Phe; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With piperidine; In N,N-dimethyl-formamide;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Further stages;

DOI:10.1016/j.tetlet.2017.03.021

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

N-Fmoc L-Phe

N-Fmoc-β-alanine

Downstream raw materials:

benzoyl-Gly-Phe-Gly

formaldehyd

carbon dioxide

phenylacetaldehyde

Refernces

• 1、 Mayer, Clemens,Hilvert, Donald. "A genetically encodable ligand for transfer hydrogenation". supporting information. p. 3427 - 3431. Retrieved 2013/07/19.