4-(ChloroMethyl)-N-cyclopropylbenzaMide

Base Information

• Chemical Name: 4-(ChloroMethyl)-N-cyclopropylbenzaMide
• CAS No.: 873371-67-6
• Molecular Formula: C11H12ClNO
• Molecular Weight: 209.675
• Mol file: 873371-67-6.mol

Synonyms:4-chloromethyl-N-cyclopropyl-benzamide;

Chemical Property of 4-(ChloroMethyl)-N-cyclopropylbenzaMide

Chemical Property:

• PSA: 29.10000
• LogP: 2.70850

Purity/Quality:

≥95% ^*data from raw suppliers

4-(Chloromethyl)-N-cyclopropylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ChloroMethyl)-N-cyclopropylbenzaMide

There total 2 articles about 4-(ChloroMethyl)-N-cyclopropylbenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-(chloromethyl)benzoic acid (1642-81-5) + Cyclopropylamine (765-30-0) → 4-chloromethylbenzoic acid cyclopropyl amide (873371-67-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2018.04.048

Reference yield:

→ 4-chloromethylbenzoic acid cyclopropyl amide (873371-67-6)

Guidance literature:

Product distribution / selectivity;

Reference yield: 62.0%

4-chloromethylbenzoic acid cyclopropyl amide (873371-67-6) + 4-bromo-2H-phthalazin-1-one (19064-73-4) → 4-((4-bromo-1-oxophthalazine-2(1H)-yl)methyl)benzoic acid cyclopropyl amide

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 48.5h;

DOI:10.1016/j.bmc.2018.04.048

upstream raw materials:

p-(chloromethyl)benzoic acid

Cyclopropylamine