3-Oxazolidinecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-, [4-[[(2S)-2-amino-1-oxopropyl]amino]phenyl]methyl ester

Base Information

• Chemical Name: 3-Oxazolidinecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-, [4-[[(2S)-2-amino-1-oxopropyl]amino]phenyl]methyl ester
• CAS No.: 873923-26-3
• Molecular Formula: C₃₃H₄₃N₃O₅Si
• Molecular Weight: 589.807
• Mol file: 873923-26-3.mol

Synonyms:

Chemical Property of 3-Oxazolidinecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-, [4-[[(2S)-2-amino-1-oxopropyl]amino]phenyl]methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxazolidinecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-, [4-[[(2S)-2-amino-1-oxopropyl]amino]phenyl]methyl ester

There total 5 articles about 3-Oxazolidinecarboxylic acid, 2-[3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]propyl]-, [4-[[(2S)-2-amino-1-oxopropyl]amino]phenyl]methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-benzyl ester (923925-83-1) → 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-(2-amino-propionylamino)-benzyl ester (873923-26-3)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.09.081

Reference yield:

2-(3-(tert-butyldiphenylsilyloxy)propyl)oxazolidine (873923-25-2) → 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-(2-amino-propionylamino)-benzyl ester (873923-26-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / CH₂Cl₂ / 2 h / -78 °C

1.2: 61 percent / CH₂Cl₂ / -78 - 20 °C

2.1: piperidine / dimethylformamide

With piperidine; pyridine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2005.09.081

Reference yield:

4-((tert-butyldiphenylsilyl)oxy)butanal (127793-62-8) → 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-(2-amino-propionylamino)-benzyl ester (873923-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: benzene

2.1: pyridine / CH₂Cl₂ / 2 h / -78 °C

2.2: 61 percent / CH₂Cl₂ / -78 - 20 °C

3.1: piperidine / dimethylformamide

With piperidine; pyridine; In dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1016/j.bmcl.2005.09.081

upstream raw materials:

2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-benzyl ester

2-(3-(tert-butyldiphenylsilyloxy)propyl)oxazolidine

4-((tert-butyldiphenylsilyl)oxy)butanal

4-(tret-butyldiphenylsilyloxy)butan-1-ol

Downstream raw materials:

2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-propionylamino}-benzyl ester

2-(3-Hydroxy-propyl)-oxazolidine-3-carboxylic acid 4-[(S)-2-((S)-2-amino-3-methyl-butyrylamino)-propionylamino]-benzyl ester

2-(3-Oxo-propyl)-oxazolidine-3-carboxylic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-methyl-butyrylamino}-propionylamino)-benzyl ester

2-(3-Hydroxy-propyl)-oxazolidine-3-carboxylic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-methyl-butyrylamino}-propionylamino)-benzyl ester