Propanoic acid, 2,2-dimethyl-, 3-acetyl-4-methoxyphenyl ester

Base Information

• Chemical Name: Propanoic acid, 2,2-dimethyl-, 3-acetyl-4-methoxyphenyl ester
• CAS No.: 874130-66-2
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol file: 874130-66-2.mol

Synonyms:

Chemical Property of Propanoic acid, 2,2-dimethyl-, 3-acetyl-4-methoxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 2,2-dimethyl-, 3-acetyl-4-methoxyphenyl ester

There total 3 articles about Propanoic acid, 2,2-dimethyl-, 3-acetyl-4-methoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,2-dimethylpropionic acid 3-acetyl-4-hydroxyphenyl ester (874130-59-3) + methyl iodide (74-88-4) → 2,2-dimethylpropionic acid 3-acetyl-4-methoxyphenyl ester (874130-66-2)

Guidance literature:

With lithium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 4h;

DOI:10.1039/b512851j

Reference yield:

pivaloyl chloride (3282-30-2) → 2,2-dimethylpropionic acid 3-acetyl-4-methoxyphenyl ester (874130-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / pyridine / 1 h / 20 °C

2: 82 percent / Li₂CO₃ / dimethylformamide / 4 h / 120 °C

With pyridine; lithium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/b512851j

Reference yield:

2,5-Dihydroxyacetophenone (490-78-8) → 2,2-dimethylpropionic acid 3-acetyl-4-methoxyphenyl ester (874130-66-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / pyridine / 1 h / 20 °C

2: 82 percent / Li₂CO₃ / dimethylformamide / 4 h / 120 °C

With pyridine; lithium carbonate; In N,N-dimethyl-formamide;

DOI:10.1039/b512851j

upstream raw materials:

2,2-dimethylpropionic acid 3-acetyl-4-hydroxyphenyl ester

methyl iodide

pivaloyl chloride

2,5-Dihydroxyacetophenone

Downstream raw materials:

2-iodo-3-methoxy-5-methylbenzoic acid 3-acetyl-4-methoxyphenyl ester

2,2-dimethylpropionic acid 3-(2-(ethoxythiocarbonylsulfanyl)acetyl)-4-methoxyphenyl ester

1-(5-hydroxy-2-methoxyphenyl)ethan-1-one