1,3,6,9,12,15,18,21-Octaoxacyclotetracosane

Base Information

• Chemical Name: 1,3,6,9,12,15,18,21-Octaoxacyclotetracosane
• CAS No.: 33089-37-1
• Molecular Formula: C16H32O8
• Molecular Weight: 352.425
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID80954714
• Mol file: 33089-37-1.mol

Synonyms:1,3,6,9,12,15,18,21-octaoxacyclotetracosane;BRN 1686140;EINECS 251-374-9;DTXSID80954714

Chemical Property of 1,3,6,9,12,15,18,21-Octaoxacyclotetracosane

Chemical Property:

• Vapor Pressure: 2.18E-09mmHg at 25°C
• Refractive Index: 1.404
• Boiling Point: 497.6 °C at 760 mmHg
• Flash Point: 202.8 °C
• PSA: 73.84000
• Density: 0.995 g/cm³
• LogP: 0.13280
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 352.20971797
• Heavy Atom Count: 24
• Complexity: 242

Purity/Quality:

98%,99%, ^*data from raw suppliers

24-Crown 8-Ether >95.0%(GC) ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCOCCOCCOCCOCCOCCOCOC1

Technology Process of 1,3,6,9,12,15,18,21-Octaoxacyclotetracosane

There total 11 articles about 1,3,6,9,12,15,18,21-Octaoxacyclotetracosane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) + Tetraethylene glycol (112-60-7) → 24-crown-8 (33089-37-1) + 48-Crown-16 (71092-61-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) 40 min, 2.) 67 deg C, 34 h;

DOI:10.1021/jo00087a040

Reference yield: 39.0%

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) + Tetraethylene glycol (112-60-7) → 24-crown-8 (33089-37-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 22 - 24 ℃; for 96h;

DOI:10.1080/00397919908085989

Reference yield: 23.0%

Tetraethylene glycol (112-60-7) → (1,4,7,10-tetraoxacyclododecane) (294-93-9,64491-37-8) + 24-crown-8 (33089-37-1) + <36>crown-12 (71092-59-6) + 48-Crown-16 (71092-61-0)

Guidance literature:

With potassium hydroxide; p-toluenesulfonyl chloride; In 1,4-dioxane; at 65 ℃; Further byproducts given;

DOI:10.1016/S0040-4020(01)80080-6

upstream raw materials:

tetraethylene glycol di(p-toluenesulfonate)

Tetraethylene glycol

octaethylene glycol

diethylene glycol

Refernces

• 1、 Borodin, Oleg,Richter, Stefan,Robertson, Craig C.,Shchukin, Yevhenii,Von Delius, Max. "Self-Assembly of Stimuli-Responsive [2]Rotaxanes by Amidinium Exchange". supporting information. p. 16448 - 16457. Retrieved 2021/10/12.
• 2、 Gibson, Harry W.,Bheda, Mukesh C.,Engen, Paul,Shen, Ya Xi,Sze, Jean,et al.. "Synthesis and Characterization of Large (30-60-Membered) Aliphatic Crown Ethers". . p. 2186 - 2196. Retrieved 2007/10/02.