1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

Base Information

Chemical Name:1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene
CAS No.:875446-57-4
Molecular Formula:C10H12FIO
Molecular Weight:294.108
Hs Code.:
DSSTox Substance ID:DTXSID50693643
Wikidata:Q82622654

Synonyms:875446-57-4;1-FLUORO-4-IODO-2-ISOPROPYL-5-METHOXYBENZENE;1-Fluoro-4-iodo-5-methoxy-2-(propan-2-yl)benzene;1-fluoro-4-iodo-5-methoxy-2-propan-2-ylbenzene;SCHEMBL531643;DTXSID50693643;ZGDIITXZQPZANU-UHFFFAOYSA-N;PB36300;SB20516;CS-0057507;FT-0765891;A1-24163

Suppliers and Price of 1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:293.99169
Heavy Atom Count:13
Complexity:163

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C1=CC(=C(C=C1F)OC)I

Technology Process of 1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene

There total 4 articles about 1-Fluoro-4-iodo-2-isopropyl-5-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1262414-96-9
2-(2-fluoro-4-methoxyphenyl)isopropane

: 875446-57-4
1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene

Guidance literature:: With iodine; silver sulfate; In methanol; for 8h; Darkness;
DOI:10.1021/jacs.9b03375

Reference yield:

: 875446-55-2
2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene

: 875446-57-4
1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene

Guidance literature:: 2-fluoro-4-methoxy-1-(prop-1-en-2-yl)benzene; With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h; under 760.051 Torr;

With iodine; silver sulfate; In methanol; at 20 ℃; for 3h;

Reference yield:

: 74457-86-6
1-(2-fluoro-4-methoxyphenyl)-1-ethanone

: 875446-57-4
1-fluoro-4-iodo-2-isopropenyl-5-methoxybenzene

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 25 °C / 760.05 Torr

4: iodine; silver sulfate / methanol / 3 h / 25 °C

With palladium 10% on activated carbon; hydrogen; iodine; silver sulfate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm200484c