N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine

Base Information

• Chemical Name: N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine
• CAS No.: 877149-80-9
• Molecular Formula: C13H24BN3O2
• Molecular Weight: 265.163
• Hs Code.: 2934999090
• Mol file: 877149-80-9.mol

Synonyms:N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]ethanamine;

Chemical Property of N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 365.765oC at 760 mmHg
• Flash Point: 175.009oC
• PSA: 39.52000
• Density: 1.041g/cm3
• LogP: 0.74390
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethanamine 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine

There total 7 articles about N,N-DiMethyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + (2-chloroethyl)dimethylamine hydrochloride (4584-46-7) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine (877149-80-9)

Guidance literature:

With caesium carbonate; In acetonitrile; for 5h; Reflux;

Reference yield: 85.2%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + 2-(dimethylamino)ethyl bromide hydrobromide (2862-39-7) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine (877149-80-9)

Guidance literature:

With caesium carbonate; In acetonitrile; at 80 ℃; for 12h;

Reference yield: 76.0%

1-(2-chloroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (877149-79-6) + dimethyl amine (124-40-3) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)ethan-1-amine (877149-80-9)

Guidance literature:

1-(2-chloroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; dimethyl amine; In tetrahydrofuran; at 20 ℃; for 48h;

With potassium iodide; In tetrahydrofuran; at 75 ℃; for 48h;

upstream raw materials:

1-(2-chloroethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

dimethyl amine

pyrazole-4-boronic acid pinacol ester

2-(dimethylamino)ethyl chloride

Downstream raw materials:

5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-amine

N-(5-(5-(1-(2-(dimethylamino)ethyl)-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-2',4'-difluorobiphenyl-3-yl)methanesulfonamide

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