alpha-methoxy-p-xylene

Base Information

• Chemical Name: alpha-methoxy-p-xylene
• CAS No.: 3395-88-8
• Molecular Formula: C9H12 O
• Molecular Weight: 136.194
• Hs Code.: 2909309090
• European Community (EC) Number: 222-245-4
• DSSTox Substance ID: DTXSID90950444
• Nikkaji Number: J32.104D
• Wikidata: Q82928511
• Mol file: 3395-88-8.mol

Synonyms:Ether,methyl p-methylbenzyl (6CI,7CI,8CI); 1-(Methoxymethyl)-4-methylbenzene;4-(Methoxymethyl)toluene; 4-Methylbenzyl methyl ether; Methyl4-methylphenylmethyl ether; Methyl p-methylbenzyl ether;p-(Methoxymethyl)toluene; p-Methylbenzyl methyl ether; a-Methoxy-p-xylene

Chemical Property of alpha-methoxy-p-xylene

Chemical Property:

• Boiling Point: 175.6°Cat760mmHg
• Flash Point: 54.8°C
• PSA: 9.23000
• Density: 0.939g/cm³
• LogP: 2.14140
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 136.088815002
• Heavy Atom Count: 10
• Complexity: 82.7

Purity/Quality:

99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)COC

Technology Process of alpha-methoxy-p-xylene

There total 42 articles about alpha-methoxy-p-xylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(dimethoxy)methylsilane (16881-77-9) + 4-methyl-benzaldehyde (104-87-0) → 4-methylbenzyl methyl ether (3395-88-8)

Guidance literature:

(dimethoxy)methylsilane; 4-methyl-benzaldehyde; With dicarbonyl(pentamethylcyclopentadienyl)(4-methoxyphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 96.0%

methanol (67-56-1) + 4-Methylbenzyl alcohol (589-18-4) → 4-methylbenzyl methyl ether (3395-88-8)

Guidance literature:

With ytterbium(III) triflate; at 145 ℃; for 3h; microwave irradiation;

DOI:10.1055/s-2004-836063

Reference yield: 93.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-Methylbenzyl bromide (104-81-4) → 4-methylbenzyl methyl ether (3395-88-8) + methyl p-tolylacetate (23786-13-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; C₂₆H₂₄BrOPPd; triphenylphosphine; at 28 - 47 ℃; under 2587.76 Torr; Conversion of starting material;

upstream raw materials:

chloromethyl methyl ether

benzylmagnesium chloride

sodium methylate

4-Methylbenzyl bromide

Downstream raw materials:

CH₃C₆H₄CH(CH₃)OH

4-methyl-benzoic acid methyl ester

S-cyclohexyl 4-methylbenzothioate

2-(4-methylphenyl)-1,3-benzothiazole