Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol

Base Information

Chemical Name:Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol
CAS No.:88184-87-6
Molecular Formula:C17H20N2O3S
Molecular Weight:332.423
Hs Code.:
DSSTox Substance ID:DTXSID80516912

Synonyms:88184-87-6;Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol;DTXSID80516912

Suppliers and Price of Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:332.11946368
Heavy Atom Count:23
Complexity:465

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(CC1)S(=O)(=O)C2=C(C=CN=C2)C(C3=CC=CC=C3)O

Technology Process of Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol

There total 3 articles about Phenyl[3-(piperidine-1-sulfonyl)pyridin-4-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 636-73-7
3-pyridinesulfonic acid

: 88184-87-6
Phenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: PCl₅ / 3 h / Heating

2: benzene / 0.5 h / 0 °C

3: 1.) butyllithium, diisopropylamine / 1.) Et₂O, -70 deg C, 1 h; 2.) Et₂O, -70 deg C, 2 h

With n-butyllithium; phosphorus pentachloride; diisopropylamine; In benzene;
DOI:10.1055/s-1983-30528

Reference yield:

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 88184-87-6
Phenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1: benzene / 0.5 h / 0 °C

2: 1.) butyllithium, diisopropylamine / 1.) Et₂O, -70 deg C, 1 h; 2.) Et₂O, -70 deg C, 2 h

With n-butyllithium; diisopropylamine; In benzene;
DOI:10.1055/s-1983-30528

Reference yield:

: 100-52-7
benzaldehyde

: 26103-49-1
3-(piperidin-1-ylsulfonyl)pyridine

: 88184-87-6
Phenyl-[3-(piperidine-1-sulfonyl)-pyridin-4-yl]-methanol

Guidance literature:: With n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1.) Et₂O, -70 deg C, 1 h; 2.) Et₂O, -70 deg C, 2 h;
DOI:10.1055/s-1983-30528