1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine

Base Information

Chemical Name:1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine
CAS No.:886230-76-8
Molecular Formula:C19H20N4O
Molecular Weight:320.394
Hs Code.:
DSSTox Substance ID:DTXSID00694701
Mol file:886230-76-8.mol

Synonyms:DTXSID00694701;1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine

Suppliers and Price of 1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AxitinibPyran
10mg
$ 165.00

Total 63 raw suppliers

Chemical Property of 1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine

Chemical Property:

Boiling Point:562.828 °C at 760 mmHg
PKA:4.31±0.10(Predicted)
Flash Point:294.188 °C
PSA：65.96000
Density:1.293 g/cm³
LogP:4.46420
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:320.16371127
Heavy Atom Count:24
Complexity:443

Purity/Quality:

99%, ^*data from raw suppliers

AxitinibPyran ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCOC(C1)N2C3=C(C=CC(=C3)N)C(=N2)C=CC4=CC=CC=N4
Uses (E)-3-[2-(Pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-amine is a heterocyclic derivative and can be used as a pharmaceutical intermediate. Axitinib Pyran is a reagent used in synthesis of anti-angiogenic TKI-PET tracers.

Technology Process of 1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine

There total 12 articles about 1-(Oxan-2-yl)-3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.38%

: 886230-75-7
(Ε)-6-nitro-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

: 886230-76-8
(Ε)-6-amino-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

Guidance literature:: With sodiumsulfide nonahydrate; In methanol; at 65 ℃; for 3h; Temperature;

Reference yield:

: C₁₉H₁₈N₄O₃

: 886230-76-8
(Ε)-6-amino-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

Guidance literature:: With iron; ammonium chloride;

Reference yield:

: 7597-18-4
6-nitroindazole

: 886230-76-8
(Ε)-6-amino-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)indazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; iodine / N,N-dimethyl-formamide / 25 °C

2: methanesulfonic acid / dichloromethane; tetrahydrofuran / 5 h / 25 °C

3: N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 12 h / 100 °C

4: ammonium chloride; iron / ethanol; water / 2 h / 50 °C

With methanesulfonic acid; iodine; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;