1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol

Base Information

• Chemical Name: 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol
• CAS No.: 14944-28-6
• Molecular Formula: C₁₁H₁₄O
• Molecular Weight: 162.232
• Mol file: 14944-28-6.mol

Synonyms:1-Naphthol,1,2,3,4-tetrahydro-1-methyl- (6CI,7CI,8CI); (RS)-1-Hydroxy-1-methyltetralin;1,2,3,4-Tetrahydro-1-methyl-1-naphthalenol; 1-Hydroxy-1-methyltetralin;1-Methyl-1,2,3,4-tetrahydronaphthalen-1-ol

Chemical Property of 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol

Chemical Property:

• Vapor Pressure: 0.00343mmHg at 25°C
• Boiling Point: 270.1°Cat760mmHg
• Flash Point: 102°C
• Density: 1.069g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol

There total 13 articles about 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methylmagnesium chloride (676-58-4) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (39202-04-5,14944-28-6)

Guidance literature:

3,4-dihydronaphthalene-1(2H)-one; With lanthanium (III) chloride bis(lithium chloride) complex; In tetrahydrofuran; for 1h; Inert atmosphere;

methylmagnesium chloride; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1217169

Reference yield: 92.0%

methylmagnesium bromide (75-16-1) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (39202-04-5,14944-28-6)

Guidance literature:

In diethyl ether; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ja404342j

Reference yield: 90.0%

methyl magnesium iodide (917-64-6) + 3,4-dihydronaphthalene-1(2H)-one (529-34-0) → 1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (39202-04-5,14944-28-6)

Guidance literature:

methyl magnesium iodide; With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃;

3,4-dihydronaphthalene-1(2H)-one; In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h;

DOI:10.1039/b926243a

upstream raw materials:

methyl magnesium iodide

3,4-dihydronaphthalene-1(2H)-one

methylmagnesium chloride

methyltriisopropoxytitanium(IV)

Downstream raw materials:

5-(o-hydroxyphenyl)-2-pentanone

(E)-methyl 5-(2-acetylphenyl)pent-2-enoate

3-(2-acetylphenyl)propanal

1-methyl-1,2,3,4-tetrahydronaphthalene-r-1,c-2-diol