N-(Methoxymethyl)-4-methylaniline

Base Information

• Chemical Name: N-(Methoxymethyl)-4-methylaniline
• CAS No.: 88919-94-2
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• DSSTox Substance ID: DTXSID10539533
• Wikidata: Q82415308
• Mol file: 88919-94-2.mol

Synonyms:N-(Methoxymethyl)-4-methylaniline;88919-94-2;SCHEMBL11768142;DTXSID10539533

Chemical Property of N-(Methoxymethyl)-4-methylaniline

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NCOC

Technology Process of N-(Methoxymethyl)-4-methylaniline

There total 3 articles about N-(Methoxymethyl)-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Dimethoxymethane (109-87-5) + p-toluidine (106-49-0,12221-03-3) → 4-toluidine (88919-94-2)

Guidance literature:

With poly(4-vinylpyridine) supported copper(II) oxide nanoparticles; In neat (no solvent); at 20 ℃; for 0.166667h; chemoselective reaction;

DOI:10.1007/s13738-016-0887-x

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + sodium methylate (124-41-4) + p-toluidine (106-49-0,12221-03-3) → 4-toluidine (88919-94-2)

Guidance literature:

In methanol; Ambient temperature;

DOI:10.1039/c39830001109

Reference yield:

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + p-toluidine (106-49-0,12221-03-3) → 4-toluidine (88919-94-2)

Guidance literature:

With sodium; Yield given. Multistep reaction; 3.) r.t., 5 h;

DOI:10.1039/P19880001631

upstream raw materials:

methanol

formaldehyd

p-toluidine

sodium methylate

Downstream raw materials:

bis(4-methylphenylamino)methane

1,3,5-tris(p-tolyl)hexahydro-s-triazine

Refernces

• 1、 Barluenga, Jose,Bayon, Ana M.,Campos, Pedro,Asensio, Gregorio,Gonzalez-Nunez, Elena,Molina, Yolanda. "Preparation of N,O-Aminals as Synthetic Equivalents of H2C=NAr and (H2C=NHAr)+ ions: Neutral- and Acid-promoted Transformations". . p. 1631 - 1636. Retrieved 2007/10/02.