N-(methoxymethyl)aniline

Base Information

• Chemical Name: N-(methoxymethyl)aniline
• CAS No.: 88933-19-1
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• DSSTox Substance ID: DTXSID80394555
• Nikkaji Number: J689.395C
• Mol file: 88933-19-1.mol

Synonyms:N-(methoxymethyl)aniline;88933-19-1;Benzenamine, N-(methoxymethyl)-;SCHEMBL2721214;DTXSID80394555;AKOS006348048

Chemical Property of N-(methoxymethyl)aniline

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 79.3

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCNC1=CC=CC=C1

Technology Process of N-(methoxymethyl)aniline

There total 4 articles about N-(methoxymethyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Dimethoxymethane (109-87-5) + aniline (62-53-3) → methoxymethylphenylamine (88933-19-1)

Guidance literature:

With poly(4-vinylpyridine) supported copper(II) oxide nanoparticles; In neat (no solvent); at 20 ℃; for 0.25h; chemoselective reaction;

DOI:10.1007/s13738-016-0887-x

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + sodium methylate (124-41-4) + aniline (62-53-3) → methoxymethylphenylamine (88933-19-1)

Guidance literature:

In methanol; Ambient temperature;

DOI:10.1039/c39830001109

Reference yield: 85.0%

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + aniline (62-53-3) → methoxymethylphenylamine (88933-19-1)

Guidance literature:

With sodium; 3.) r.t., 5 h; method for the synthesis of N,O-aminals (further alcohols and aromatic amines);

DOI:10.1039/P19880001631

upstream raw materials:

methanol

formaldehyd

aniline

sodium methylate

Downstream raw materials:

N,N-Diethyl-N'-phenyl-but-2-yne-1,4-diamine

1,4-dianilino-2-butyne

N-pentylaniline

Non-2-ynyl-phenyl-amine