2,2,3-Triphenyl-1-azabicyclo[1.1.0]butane

Base Information

• Chemical Name: 2,2,3-Triphenyl-1-azabicyclo[1.1.0]butane
• CAS No.: 89030-16-0
• Molecular Formula: C21H17N
• Molecular Weight: 283.373
• DSSTox Substance ID: DTXSID90524886
• Mol file: 89030-16-0.mol

Synonyms:2,2,3-triphenyl-1-azabicyclo[1.1.0]butane;89030-16-0;2,2,3-triphenyl-1-azabicyclo[1.1.0]butan;DTXSID90524886;AKOS015906905

Chemical Property of 2,2,3-Triphenyl-1-azabicyclo[1.1.0]butane

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 283.136099547
• Heavy Atom Count: 22
• Complexity: 394

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2(N1C2(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5

Technology Process of 2,2,3-Triphenyl-1-azabicyclo[1.1.0]butane

There total 6 articles about 2,2,3-Triphenyl-1-azabicyclo[1.1.0]butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4,4,5-Triphenyl-3-oxa-1-aza-bicyclo[3.1.0]hexan-2-one (64890-04-6) → benzophenone (119-61-9) + 2,3,3-triphenylacrylaldehyde (25683-83-4) + 2,2,3-triphenyl-1-azabicyclo<1.1.0>butane (89030-16-0)

Guidance literature:

With perdeuteriopyridine; In acetonitrile; at 20 ℃; for 25h; Product distribution; Irradiation; further bicyclocarbamates or -thiocarbamates;

Reference yield: 77.0%

4,4,5-Triphenyl-3-oxa-1-aza-bicyclo[3.1.0]hexan-2-one (64890-04-6) → 2,3,3-triphenylacrylaldehyde (25683-83-4) + 2,2,3-triphenyl-1-azabicyclo<1.1.0>butane (89030-16-0)

Guidance literature:

In acetonitrile; for 20h; Irradiation;

DOI:10.1016/S0040-4039(00)88298-2

Reference yield:

diphenyl(2-phenyl-aziridin-2-yl)methanol (64889-89-0) → 2,2,3-triphenyl-1-azabicyclo<1.1.0>butane (89030-16-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Et₃N / diethyl ether / 2 h / Ambient temperature

2: 96 percent / Et₃N / 10 h / Heating

3: 77 percent / pyridine-d5 / acetonitrile / 25 h / 20 °C / Irradiation

With perdeuteriopyridine; triethylamine; In diethyl ether; acetonitrile;

upstream raw materials:

4,4,5-Triphenyl-3-oxa-1-aza-bicyclo[3.1.0]hexan-2-one

diphenyl(2-phenyl-aziridin-2-yl)methanol

Carbonic acid diphenyl-(2-phenyl-aziridin-2-yl)-methyl ester ethyl ester

1-hydroxy-1,1-diphenylpropan-2-one oxime