5,6,7,8-Tetrafluoroquinoline

Base Information

• Chemical Name: 5,6,7,8-Tetrafluoroquinoline
• CAS No.: 5280-07-9
• Molecular Formula: C₉H₃F₄N
• Molecular Weight: 201.123
• UNII: D6C9CK3JQC
• DSSTox Substance ID: DTXSID00200780
• Nikkaji Number: J1.068.590G
• Wikidata: Q83073945
• Mol file: 5280-07-9.mol

Synonyms:5,6,7,8-Tetrafluoroquinoline;CCRIS 8777;D6C9CK3JQC;Quinoline, 5,6,7,8-tetrafluoro-;5280-07-9;UNII-D6C9CK3JQC;DTXSID00200780;LS-188344

Chemical Property of 5,6,7,8-Tetrafluoroquinoline

Chemical Property:

• Vapor Pressure: 0.0567mmHg at 25°C
• Boiling Point: 241.1°Cat760mmHg
• Flash Point: 99.6°C
• Density: 1.505g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 201.02016175
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C(C(=C2F)F)F)F)N=C1

Technology Process of 5,6,7,8-Tetrafluoroquinoline

There total 2 articles about 5,6,7,8-Tetrafluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,3,4,5-tetrafluoroaniline (5580-80-3) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 5,6,7,8-Tetrafluoroquinoline (5280-07-9)

Guidance literature:

With sulfuric acid; sodium 3-nitrobenzenesulfonate; at 140 ℃; for 4h;

DOI:10.1016/S1383-5718(98)00188-0

Reference yield:

→ 5,6,7,8-Tetrafluoroquinoline (5280-07-9)

Guidance literature:

2,3,4,5-Tetrafluor-anilin, As2O5, FeSO4*xH2O, H3BO3, Glycerin, H2SO4, 120 - 126grad;

Reference yield: 41.0%

5,6,7,8-Tetrafluoroquinoline (5280-07-9) + benzaldehyde (100-52-7) → 7-(2-benzylidenehydrazino)-5,6,8-trifluoroquinoline (1242094-93-4)

Guidance literature:

5,6,7,8-Tetrafluoroquinoline; With hydrazine hydrate; In 1,4-dioxane; for 6h; Reflux;

benzaldehyde; In ethanol; water; at 40 - 60 ℃; for 1.25h;

DOI:10.1007/s11172-009-0134-z

upstream raw materials:

2,3,4,5-tetrafluoroaniline

glycerol

Downstream raw materials:

5,6,8-Trifluoroquinoline

6-amino-5,8-difluoroquinoline

8-amino-5,6-difluoroquinoline

7-(2-benzylidenehydrazino)-5,6,8-trifluoroquinoline