2,5-Dichloro-4-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2,5-Dichloro-4-(trifluoromethyl)pyridine
• CAS No.: 89719-92-6
• Molecular Formula: C6H2Cl2F3N
• Molecular Weight: 215.99
• Hs Code.: 2933399090
• Mol file: 89719-92-6.mol

Synonyms:2,5-dichloro-4-trifluoromethylpyridine;2,4-DICHLOROPHENYLMETHYL IODIDE;Pyridine,2,5-dichloro-4-(trifluoromethyl);

Chemical Property of 2,5-Dichloro-4-(trifluoromethyl)pyridine

Chemical Property:

• Refractive Index: n20/D1.482
• Boiling Point: 76℃/18mm
• Flash Point: >110℃
• PSA: 12.89000
• Density: 1.542 g/mL at 25 °C
• LogP: 3.40720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dichloro-4-(trifluoromethyl)pyridine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-chloro-6-(trifluoromethyl)pyridine, 2-chloro-5-(trifluoromethyl)pyridine and 3-chloro-4-(trifluoromethyl)pyridine were each converted into the three possible carboxylic acids 2, 4, 6,8, 10, 12, 16, 17 and 20. This was achieved by employing several, but not all of the organometallic ?toolbox methods?: transformation of a more basic organometallic species into a less basic isomer by transmetalation-equilibration.

Technology Process of 2,5-Dichloro-4-(trifluoromethyl)pyridine

There total 1 articles about 2,5-Dichloro-4-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(trifluoromethyl)trimethylsilane (81290-20-2) + 2,5-dichloro-4-iodo-pyridine (796851-03-1) → 2,5-dichloro-4-(trifluoromethyl)pyridine (89719-92-6)

Guidance literature:

(trifluoromethyl)trimethylsilane; With 1-Methylpyrrolidine; potassium fluoride; copper(l) iodide; at 50 ℃; for 1.16667h; Heating / reflux;

2,5-dichloro-4-iodo-pyridine; for 20h;

With ammonia; water;

Reference yield: 57.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + 2,5-dichloro-4-(trifluoromethyl)pyridine (89719-92-6) → ethyl 5-chloro-4-(trifluoromethyl)picolinate

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; In ethanol; at 60 ℃; for 16h; under 15201 Torr;

Reference yield: 12.0%

2,5-dichloro-4-(trifluoromethyl)pyridine (89719-92-6) + tert-butyl 5-cyclopropyl-2-fluoro-4-((4-hydroxy-4-methylpiperidin-1-yl)methyl)benzoate → tert-butyl 4-((4-((5-chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)-4-methylpiperidin-1-yl)methyl)-5-cyclopropyl-2-fluorobenzoate

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 80 - 100 ℃; for 48h;

upstream raw materials:

(trifluoromethyl)trimethylsilane

2,5-dichloro-4-iodo-pyridine

Downstream raw materials:

5-chloro-4-(trifluoromethyl)picolinonitrile

4-((5-chloro-4-(trifluoromethyl)pyridin-2-yl)oxy)-N-(N,N-dimethylsulfamoyl)-2,5-difluorobenzamide

5-chloro-4-(trifluoromethyl)picolinic acid