2-Amino-5-iodo-N-methylbenzamide

Base Information

• Chemical Name: 2-Amino-5-iodo-N-methylbenzamide
• CAS No.: 32615-70-6
• Molecular Formula: C8H9IN2O
• Molecular Weight: 276.077
• Mol file: 32615-70-6.mol

Synonyms:

Chemical Property of 2-Amino-5-iodo-N-methylbenzamide

Chemical Property:

• Vapor Pressure: 1.17E-05mmHg at 25°C
• Boiling Point: 369.7°Cat760mmHg
• Flash Point: 177.4°C
• PSA: 58.61000
• Density: 1.791g/cm³
• LogP: 2.38900

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-5-IODO-N-METHYLBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-5-iodo-N-methylbenzamide

There total 7 articles about 2-Amino-5-iodo-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-amino-5-iodobenzoic acid (5326-47-6) + methylamine (74-89-5) → 2-amino-5-iodo-N-methylbenzamide (32615-70-6)

Guidance literature:

2-amino-5-iodobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 3h; Heating / reflux;

methylamine; In tetrahydrofuran; for 2h; Heating / reflux;

Reference yield: 53.0%

methylamine hydrochloride (593-51-1) + 2-amino-5-iodobenzoic acid (5326-47-6) → 2-amino-5-iodo-N-methylbenzamide (32615-70-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1039/d0ob00866d

Reference yield:

methyl 2-amino-5-iodobenzoate (77317-55-6) + methylamine (74-89-5) → 2-amino-5-iodo-N-methylbenzamide (32615-70-6)

Guidance literature:

for 5h; Reflux;

DOI:10.1134/S1070363216020286

upstream raw materials:

5-iodoisatoic anhydride

methylamine

2-amino-5-iodobenzoic acid

2-carbomethoxyaniline

Downstream raw materials:

6-iodo-3-methylquinazolin-4-one