4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E )-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

Base Information

Chemical Name:4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E )-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-
CAS No.:904930-00-3
Molecular Formula:C30H49IN2O3Si
Molecular Weight:640.721
Hs Code.:

4(1H)-Pyridinone,
2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E
)-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

Synonyms:

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Chemical Property of 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E )-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

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Technology Process of 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E )-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)-

There total 4 articles about 4(1H)-Pyridinone, 2-[6-[[(1,1-dimethylethyl)dimethylsilyl]oxy]hexyl]-2,3-dihydro-5-iodo-1-[(E )-[[(1S)-1-(methoxymethyl)-2-methylpropyl]imino]phenylmethyl]-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 904929-91-5
(2R)-2-(6-{(tert-butyl(dimethyl)silyl)oxy}heptyl)-1-((E)-{((1S)-1-(methoxymethyl)-2-methylpropyl)imino}(phenyl)methyl)-2,3-dihydropyridin-4(1H)-one

: 904930-00-3
2-[6-(tert-butyl-dimethyl-silanyloxy)-hexyl]-5-iodo-1-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: With Iodine monochloride; caesium carbonate; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/ol0609006

Reference yield:

: Trifluoro-methanesulfonate4-methoxy-1-{[(E)-(S)-1-methoxymethyl-2-methyl-propylimino]-phenyl-methyl}-pyridinium;

: 904930-00-3
2-[6-(tert-butyl-dimethyl-silanyloxy)-hexyl]-5-iodo-1-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

1.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

1.3: 70 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

2.1: ICl; Cs₂CO₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

With tert.-butyl lithium; Iodine monochloride; caesium carbonate; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0609006

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 904930-00-3
2-[6-(tert-butyl-dimethyl-silanyloxy)-hexyl]-5-iodo-1-[(1-methoxymethyl-2-methyl-propylimino)-phenyl-methyl]-2,3-dihydro-1H-pyridin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: CH₂Cl₂ / -78 - 20 °C

2.1: tert-butyllithium / diethyl ether; pentane / 1 h / -78 °C

2.2: MgBr₂*Et₂O / diethyl ether; pentane / 1 h / 20 °C

2.3: 70 percent / diethyl ether; pentane; CH₂Cl₂ / -20 °C

3.1: ICl; Cs₂CO₃ / CH₂Cl₂ / 3 h / 0 - 20 °C

With tert.-butyl lithium; Iodine monochloride; caesium carbonate; In diethyl ether; dichloromethane; pentane;
DOI:10.1021/ol0609006