Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:79925-38-5
Molecular Formula:C19H21Cl2NO4
Molecular Weight:398.286
Hs Code.:
European Community (EC) Number:936-015-2
UNII:KS8X6G2MLC
DSSTox Substance ID:DTXSID00359707
Nikkaji Number:J3.090.619E
Mol file:79925-38-5.mol

Synonyms:79925-38-5;Nemadipine B;Nemadipine-B;diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Felodipine Imp. C (EP);Diethyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Felodipine Impurity C;Felodipine Diethyl Ester;KS8X6G2MLC;Oprea1_026193;SCHEMBL3029888;DTXSID00359707;BLLWOXSSRQPDAT-UHFFFAOYSA-N;BCP33556;AKOS024423533;3,5-diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;FELODIPINE IMPURITY C [EP IMPURITY];FT-0672673;F19260;A899973;3,5-Diethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate;diethyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate;diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate;diethyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester;3,5-Pyridinedicarboxylic acid,4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, diethyl ester

Suppliers and Price of Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
NemadipineB
1g
$ 1555.00

TRC
NemadipineB
100mg
$ 195.00

Medical Isotopes, Inc.
NemadipineB
1 g
$ 2280.00

Medical Isotopes, Inc.
NemadipineB
100 mg
$ 660.00

Crysdot
Diethyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 97%
1g
$ 644.00

Chemenu
diethyl4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 97%
1g
$ 608.00

American Custom Chemicals Corporation
DIETHYL-4-(2,3-DICHLOROPHENYL)2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE 95.00%
100MG
$ 345.45

Total 13 raw suppliers

Chemical Property of Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Chemical Property:

Melting Point:122-124°C
PSA：64.63000
LogP:4.68320
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:397.0847635
Heavy Atom Count:26
Complexity:589

Purity/Quality:

99%, ^*data from raw suppliers

NemadipineB ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OCC)C)C
Uses A Diethyl ester analogue analogue of the calcium channel blocker Felodipine (F232375) with antihypertensive activity. Nemadipine B (Felodipine EP Impurity C) is the diethyl ester analogue analogue of the calcium channel blocker Felodipine (F232375) with antihypertensive activity.

Technology Process of Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 3 articles about Diethyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 141-97-9
ethyl acetoacetate

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 79925-38-5
4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With ammonium acetate; N-butylpyridinium tetrafluoroborate; at 100 - 110 ℃; for 3h;
DOI:10.1080/00397911.2010.525773

Reference yield: 66.0%

: ethyl aminocrotonate

: 105-45-3
acetoacetic acid methyl ester

: 6334-18-5
2,3-dichlorobenzylaldehyde

: 72509-76-3,86189-69-7
ethyl methyl 1,4-dihydro-2,6-dimethyl-4(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate

: 91189-59-2
4-(-2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl ester

: 79925-38-5
4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: acetoacetic acid methyl ester; 2,3-dichlorobenzylaldehyde; piperidine; 2-Picolinic acid; In isopropyl alcohol; at 40 - 45 ℃; for 6h;

ethyl aminocrotonate; In isopropyl alcohol; for 4h; Heating / reflux;