Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester
CAS No.:918402-06-9
Molecular Formula:C16H16FNO2
Molecular Weight:273.307
Hs Code.:

Synonyms:Benzoic acid,4-[[[(4-fluorophenyl)methyl]amino]methyl]-,methyl ester;methyl 4-((4-fluorobenzylamino)methyl)benzoate;

Suppliers and Price of Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester

Chemical Property:

PSA：38.33000
LogP:3.29300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester

There total 1 articles about Benzoic acid, 4-[[[(4-fluorophenyl)methyl]amino]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 459-57-4
4-fluorobenzaldehyde

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 918402-06-9
methyl 4-((4-fluorobenzylamino)methyl)benzoate

Guidance literature:: 4-fluorobenzaldehyde; methyl 4-(aminomethyl)benzoate hydrochloride; With triethylamine; In dichloromethane; isopropyl alcohol; at 20 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In dichloromethane; isopropyl alcohol; at 20 ℃;

With sodium hydrogencarbonate; In methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 918402-06-9
methyl 4-((4-fluorobenzylamino)methyl)benzoate

: 23378-88-3
3,5-dichloro-2-hydroxybenzenesulfonyl chloride

: C₂₂H₁₈Cl₂FNO₅S

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 918402-06-9
methyl 4-((4-fluorobenzylamino)methyl)benzoate

: 1201663-69-5
4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

2.2: 0 °C / pH 3 - 4

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol;