N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Base Information

Chemical Name:N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide
CAS No.:1201662-19-2
Molecular Formula:C₂₇H₂₀Cl₂FNO₄S
Molecular Weight:544.431
Hs Code.:

Synonyms:N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Chemical Property:

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Technology Process of N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

There total 6 articles about N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1201663-72-0
4-((3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxyphenylsulfonamido)methyl)-N-methoxy-N-methylbenzamide

: 100-58-3
phenylmagnesium bromide

: 1201662-19-2
N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: In tetrahydrofuran; diethyl ether; at 20 ℃;

Reference yield:

: 918402-06-9
methyl 4-((4-fluorobenzylamino)methyl)benzoate

: 1201662-19-2
N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C

2.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

2.2: 0 °C / pH 3 - 4

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

3.2: 1 h / 20 °C

4.1: tetrahydrofuran; diethyl ether / 20 °C

With oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: C₂₂H₁₈Cl₂FNO₅S

: 1201662-19-2
N-(4-benzoylbenzyl)-3,5-dichloro-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

1.2: 0 °C / pH 3 - 4

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 20 °C

2.2: 1 h / 20 °C

3.1: tetrahydrofuran; diethyl ether / 20 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;