3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one

Base Information

Chemical Name:3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one
CAS No.:920490-79-5
Molecular Formula:C14H14BrNO3
Molecular Weight:324.174
Hs Code.:
DSSTox Substance ID:DTXSID10580823
Nikkaji Number:J2.423.786I
Wikidata:Q82471801

Synonyms:920490-79-5;3-bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one;SCHEMBL5285804;DTXSID10580823

Suppliers and Price of 3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:323.01571
Heavy Atom Count:19
Complexity:422

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN1C=C(C(=C(C1=O)Br)OC)C2=CC=C(C=C2)OC

Technology Process of 3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one

There total 3 articles about 3-Bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1h)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 920490-71-7
3-bromo-5-iodo-4-methoxy-1-methylpyridin-2(1H)-one

: 5720-07-0
4-methoxyphenylboronic acid

: 920490-79-5
3-bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one

Guidance literature:: With trisodium tris(3-sulfophenyl)phosphine; diisopropylamine; palladium diacetate; In water; acetonitrile; at 80 ℃; for 16h;
DOI:10.1021/ol062721u

Reference yield:

: 920490-72-8
3-bromo-4-methoxy-1-methylpyridin-2(1H)-one

: 920490-79-5
3-bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / N-iodosuccinimide; trifluoroacetic acid / acetonitrile / 15 h / 20 °C

2: 88 percent / tris(3-sulfonatophenyl)phosphane trisodium salt; diisopropylamine / Pd(OAc)2 / acetonitrile; H₂O / 16 h / 80 °C

With N-iodo-succinimide; trisodium tris(3-sulfophenyl)phosphine; diisopropylamine; trifluoroacetic acid; palladium diacetate; In water; acetonitrile; 2: Suzuki cross-coupling;
DOI:10.1021/ol062721u

Reference yield:

: 41759-19-7
4-methoxy-1-methyl-2-pyridone

: 920490-79-5
3-bromo-4-methoxy-5-(4-methoxyphenyl)-1-methylpyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / acetic acid; Br₂ / CH₂Cl₂ / 15 h / 20 °C

2: 95 percent / N-iodosuccinimide; trifluoroacetic acid / acetonitrile / 15 h / 20 °C

3: 88 percent / tris(3-sulfonatophenyl)phosphane trisodium salt; diisopropylamine / Pd(OAc)2 / acetonitrile; H₂O / 16 h / 80 °C

With N-iodo-succinimide; trisodium tris(3-sulfophenyl)phosphine; bromine; acetic acid; diisopropylamine; trifluoroacetic acid; palladium diacetate; In dichloromethane; water; acetonitrile; 3: Suzuki cross-coupling;
DOI:10.1021/ol062721u