Etofibrate

Base Information

Chemical Name:Etofibrate
CAS No.:31637-97-5
Molecular Formula:C18H18ClNO5
Molecular Weight:363.798
Hs Code.:2942000000
European Community (EC) Number:250-743-1
UNII:23TF67G79M
DSSTox Substance ID:DTXSID80185521
Nikkaji Number:J19.853F
Wikipedia:Etofibrate
Wikidata:Q4116990
NCI Thesaurus Code:C65588
Metabolomics Workbench ID:152057
ChEMBL ID:CHEMBL358150
Mol file:31637-97-5.mol

Synonyms:etofibrate;etofibrate hydrochloride;Lipo-Merz;Tricerol

Suppliers and Price of Etofibrate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Etofibrate
50mg
$ 100.00

TRC
Etofibrate
500mg
$ 865.00

TCI Chemical
Etofibrate
50MG
$ 174.00

TCI Chemical
Etofibrate
250MG
$ 610.00

Sigma-Aldrich
Etofibrate analytical standard
25mg
$ 97.80

DC Chemicals
Ethofibrate >98%
250 mg
$ 600.00

DC Chemicals
Ethofibrate >98%
1 g
$ 1300.00

Crysdot
Etofibrate 98%
250mg
$ 192.00

Crysdot
Etofibrate 98%
25mg
$ 57.00

Crysdot
Etofibrate 98%
10mg
$ 37.00

Total 67 raw suppliers

Chemical Property of Etofibrate

Chemical Property:

Appearance/Colour:White to off-white solid
Vapor Pressure:1.25E-09mmHg at 25°C
Melting Point:42-44 °C
Refractive Index:1.555
Boiling Point:486.8 °C at 760 mmHg
PKA:3.04±0.10(Predicted)
Flash Point:248.2 °C
PSA：74.72000
Density:1.267g/cm³
LogP:3.29260
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:7.276mg/L(room temperature)
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:363.0873504
Heavy Atom Count:25
Complexity:449

Purity/Quality:

99% ^*data from raw suppliers

Etofibrate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C(=O)OCCOC(=O)C1=CN=CC=C1)OC2=CC=C(C=C2)Cl
Description Etofibrate is a combination of niacin and clofibrate that acts as a hypolipidemic agent. In vivo, etofibrate decreases plasma cholesterol and triglyceride concentrations and increases bile cholesterol content in rats. It also decreases thromboxane formation, platelet aggregation, and plasma viscosity and inhibits neointima formation in a carotid artery balloon injury rat model. Formulations containing etofibrate have been used to treat hyperlipidemia.
Uses Antilipemic; reducing lipid levels in the blood.
Therapeutic Function Antihyperlipidemic

Technology Process of Etofibrate

There total 1 articles about Etofibrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31637-97-5
ETOFIBRATE

Guidance literature:: Na-β-nicotinat, Cl-CH2CH2-O-C(O)-C(Me)2-O-C6H4-Cl-4, Δ;

Reference yield: 99.1%

: 31637-97-5
ETOFIBRATE

: 59-67-6
nicotinic acid

: 882-09-7
Clofibric acid

: 107-21-1
ethylene glycol

Guidance literature:: With hydrogenchloride; [RuCl₂(CO)2(Ph₂P-3-C₆H₄COOH)2]; In methanol; water; at 75 ℃; for 0.333333h;
DOI:10.1016/j.saa.2007.11.001

Reference yield: 86.0%

: 1,3-dioxoisoindoline-2-yl-2-acetylamino-3-methylbutyrate

: 31637-97-5
ETOFIBRATE

: C₂₄H₂₉ClN₂O₆

Guidance literature:: With (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In 1,4-dioxane; for 14h; enantioselective reaction; Irradiation;
DOI:10.1126/science.aar6376