Glycine, N-(3,4,5-trimethoxybenzoyl)-, ethyl ester

Base Information

• Chemical Name: Glycine, N-(3,4,5-trimethoxybenzoyl)-, ethyl ester
• CAS No.: 92502-39-1
• Molecular Formula: C14H19NO6
• Molecular Weight: 297.308
• Mol file: 92502-39-1.mol

Synonyms:N-(3,4,5-Trimethoxy-benzoyl)-glycin-aethylester;N-(3,4,5-trimethoxy-benzoyl)-glycine ethyl ester;N-<3.4.5-Trimethoxy-benzoyl>-glycin-aethylester;(3.4.5-Trimethoxy-benzamino)-essigsaeure-aethylester;N-Galloylglycinaethylester;(3,4,5-Trimethoxy-benzoylamino)-acetic acid ethyl ester;

Chemical Property of Glycine, N-(3,4,5-trimethoxybenzoyl)-, ethyl ester

Chemical Property:

• PSA: 83.09000
• LogP: 1.39620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-(3,4,5-trimethoxybenzoyl)-, ethyl ester

There total 8 articles about Glycine, N-(3,4,5-trimethoxybenzoyl)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.6%

GlyOEt*HCl (459-73-4) + Eudesmic acid (118-41-2) → ethyl ((3,4,5-trimethoxybenzoyl)amino)acetate (92502-39-1)

Guidance literature:

Eudesmic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.5h;

GlyOEt*HCl; In dichloromethane; at 20 ℃; for 15h;

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + 3,4,5-Trimethoxybenzoyl chloride (4521-61-3) → ethyl ((3,4,5-trimethoxybenzoyl)amino)acetate (92502-39-1)

Guidance literature:

With sodium hydrogencarbonate;

Reference yield:

Eudesmic acid (118-41-2) → ethyl ((3,4,5-trimethoxybenzoyl)amino)acetate (92502-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / N,N-dimethylformamide / CH₂Cl₂

2: 1.83 g / N-ethyl-N,N-diisopropylamine / CH₂Cl₂

With oxalyl dichloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm060742o

upstream raw materials:

ethanol

N-(3,4,5-trimethoxy-benzoyl)-glycine nitrile

3,4,5-Trimethoxybenzoyl chloride

GlyOEt*HCl

Downstream raw materials:

N-(2-hydrazino-2-oxoethyl)-3,4,5-trimethoxybenzamide

3,4-methylenedioxy-N-(3,4,5-trimethoxy-benzoyl)-phenylalanin-ethyl ester

N-Hydroxycarbamoylmethyl-3,4,5-trimethoxy-benzamide

C₂₁H₂₁N₃O₅S