ethyl 2-(diethylamino)-5-phenyl-3H-azepine-3-carboxylate

Base Information

Chemical Name:ethyl 2-(diethylamino)-5-phenyl-3H-azepine-3-carboxylate
CAS No.:93102-69-3
Molecular Formula:C₁₉H₂₄N₂O₂
Molecular Weight:312.412
Hs Code.:
Mol file:93102-69-3.mol

Synonyms:2-Diethylamino-5-phenyl-3H-azepine-3-carboxylic acid ethyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-(diethylamino)-5-phenyl-3H-azepine-3-carboxylate

Chemical Property:

Melting Point:72.5 - 73.5 °C (hexane)
PSA：41.90000
LogP:2.95250

Purity/Quality:

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Technology Process of ethyl 2-(diethylamino)-5-phenyl-3H-azepine-3-carboxylate

There total 2 articles about ethyl 2-(diethylamino)-5-phenyl-3H-azepine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 92-93-3
1-phenyl-4-nitrobenzene

: 93102-69-3
2-(diethylamino)-3-(ethoxycarbonyl)-5-phenyl-3H-azepine

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / diethylamine / 21 h / 140 °C

2: 1.) TMP, BuLi / 1.) THF, hexane, 20 deg C, 30 min, 2.) THF, hexane, ether, -70 deg C, 20 min

With n-butyllithium; thymidine 5'-phosphate; diethylamine;

Reference yield:

: 541-41-3
chloroformic acid ethyl ester

: 41789-48-4
2-(diethylamino)-5-phenyl-3H-azepine

: 93102-69-3
2-(diethylamino)-3-(ethoxycarbonyl)-5-phenyl-3H-azepine

Guidance literature:: With n-butyllithium; thymidine 5'-phosphate; Yield given. Multistep reaction; 1.) THF, hexane, 20 deg C, 30 min, 2.) THF, hexane, ether, -70 deg C, 20 min;

Reference yield:

: 93102-69-3
2-(diethylamino)-3-(ethoxycarbonyl)-5-phenyl-3H-azepine

: 74-88-4
methyl iodide

: 110842-20-1
2-(diethylamino)-7-(ethoxycarbonyl)-7-methyl-3,4-dihydro-3,4-methano-4-phenylpyridine

Guidance literature:: With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Mechanism; 1.) THF, hexane, 20 deg C, 30 min, 2.) THF, hexane, 20 deg C, 180 min;