N,N-dimethyl-P-(trifluoromethyl)phosphonamidous chloride

Base Information

• Chemical Name: N,N-dimethyl-P-(trifluoromethyl)phosphonamidous chloride
• CAS No.: 3135-63-5
• Molecular Formula: C3H6 Cl F3 N P
• Molecular Weight: 179.5084
• Mol file: 3135-63-5.mol

Synonyms:(Dimethylamino)(trifluoromethyl)chlorophosphine

Chemical Property of N,N-dimethyl-P-(trifluoromethyl)phosphonamidous chloride

Chemical Property:

• Vapor Pressure: 74.8mmHg at 25°C
• Boiling Point: 83.6°Cat760mmHg
• Flash Point: 4.4°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-dimethyl-P-(trifluoromethyl)phosphonamidous chloride

There total 4 articles about N,N-dimethyl-P-(trifluoromethyl)phosphonamidous chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.7%

(trifluoromethyl)phosphonous dichloride (421-58-9) + dimethyl amine (124-40-3) → Chlor--trifluormethyl-phosphin (3135-63-5)

Guidance literature:

(CH3)2NH below stoich. amt.;

Reference yield:

Bis---phosphin (3205-96-7) → Chlor--trifluormethyl-phosphin (3135-63-5)

Guidance literature:

With hydrogenchloride; In diethyl ether; at -78 ℃;

DOI:10.1016/0040-4039(95)00186-G

Reference yield:

bis-(dimethylamino)methane (51-80-9) + (trifluoromethyl)phosphonous dichloride (421-58-9) → Chlor--trifluormethyl-phosphin (3135-63-5)

Guidance literature:

In diethyl ether; at 0 ℃; Yield given;

DOI:10.1016/0040-4039(95)00186-G

upstream raw materials:

(trifluoromethyl)phosphonous dichloride

dimethyl amine

bis-(dimethylamino)methane

Bis---phosphin

Downstream raw materials:

5'-O-(1,1-dianisyl-2,2,2-trichloroethyl)-3'-O-(N,N-dimethylaminotrifluoromethylphosphine) thymidine

Refernces