N-phenyl-N-(propan-2-yl)acetamide

Base Information

• Chemical Name: N-phenyl-N-(propan-2-yl)acetamide
• CAS No.: 5461-51-8
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Mol file: 5461-51-8.mol

Synonyms:

Chemical Property of N-phenyl-N-(propan-2-yl)acetamide

Chemical Property:

• Vapor Pressure: 0.0148mmHg at 25°C
• Boiling Point: 257.1°Cat760mmHg
• Flash Point: 105.3°C
• Density: 1.016g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-phenyl-N-(propan-2-yl)acetamide

There total 7 articles about N-phenyl-N-(propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Benzyl-isopropyl-amin (102-97-6) + tiolacetic acid (507-09-5) → N-isopropyl-N-phenyl-acetamide (5461-51-8)

Guidance literature:

With Fe₃O₄(at)Chit-TCT-Salen-Cu(II); In water; at 20 ℃; for 0.0833333h;

DOI:10.1007/s11164-018-3702-8

Reference yield: 71.0%

isopropyl methanesulfonate (926-06-7) + Acetanilid (103-84-4) → N-isopropyl-N-phenyl-acetamide (5461-51-8)

Guidance literature:

With tetraethylammonium tosylate; In N,N-dimethyl-formamide; electroreduction;

DOI:10.1246/cl.1986.425

Reference yield: 63.0%

2-chloro-N-(1-methylethyl)-N-phenylacetamide (1918-16-7) → N-isopropyl-N-phenyl-acetamide (5461-51-8)

Guidance literature:

With tetrabutylammonium tetrafluoroborate; triethylamine; In tetrahydrofuran; acetonitrile; at 20 ℃; for 4.4h; Inert atmosphere; Electrolysis;

DOI:10.1002/chem.201901082

upstream raw materials:

isopropyl methanesulfonate

Acetanilid

N-Isopropylaniline

2,4-dinitrophenyl acetate

Downstream raw materials:

acetic acid-(N-isopropyl-4-nitro-anilide)

N-isopropyl-N’-methyl-N,N'-diphenylethene-1,1-diamine

N-Isopropylaniline

N-ethyl-N-isopropylaniline

Refernces

1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists

10.1016/S0960-894X(01)00164-0

The research focuses on the development of 1,4-benzodiazepine derivatives as Cholecystokinin (CCK-A) receptor agonists for the treatment of obesity. The purpose of the study was to synthesize and screen a series of 1,4-benzodiazepines, specifically N-1-substituted with an N-isopropyl-N-phenylacetamide moiety, for their ability to activate CCK-A receptors, which regulate satiety and could potentially be used as a pharmacotherapeutic intervention for obesity. The researchers demonstrated in vitro agonist activity on isolated guinea pig gallbladder and in vivo induction of satiety in a rat feeding assay following intraperitoneal administration. The study concluded that a novel series of potent and efficacious 1,4-benzodiazepine and 1,4-benzodiazepine-4-N-oxide CCK-A agonists were successfully developed, which showed promising results in both in vitro and in vivo assays. Key chemicals used in the process included 3-amino-1,4-benzodiazepine core, N-isopropyl-N-phenylacetamide (agonist trigger), bromoacetamides, and various substituents at the C-3 position such as phenyl ureas, anilino acetamides, and indolylmethyl groups.