1-[Phenyl(piperidino)methyl]-2-naphthol

Base Information

• Chemical Name: 1-[Phenyl(piperidino)methyl]-2-naphthol
• CAS No.: 6278-04-2
• Molecular Formula: C22H23NO
• Molecular Weight: 317.431
• NSC Number: 35473
• Nikkaji Number: J747.058D
• ChEMBL ID: CHEMBL3794403
• Mol file: 6278-04-2.mol

Synonyms:6278-04-2;1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol;1-(PHENYL(PIPERIDIN-1-YL)METHYL)NAPHTHALEN-2-OL;1-[phenyl(piperidino)methyl]-2-naphthol;NSC35473;Maybridge2_000582;Oprea1_153169;Oprea1_253457;500352-92-1;SCHEMBL5387350;CHEMBL3794403;HMS1304K10;NSC-35473;AKOS000641903;AB03368;AB20934;AB20937;1-(phenyl-1-piperidylmethyl)-2-naphthol;AM20120409;EU-0049802;2-Naphthalenol, 1-(phenyl-1-piperidinylmethyl);1-((R)-PHENYL(PIPERIDIN-1-YL)METHYL)NAPHTHALEN-2-OL;1-((S)-PHENYL(PIPERIDIN-1-YL)METHYL)NAPHTHALEN-2-OL;521960-31-6

Chemical Property of 1-[Phenyl(piperidino)methyl]-2-naphthol

Chemical Property:

• Vapor Pressure: 1.71E-09mmHg at 25°C
• Boiling Point: 471°Cat760mmHg
• Flash Point: 234.2°C
• PSA: 23.47000
• Density: 1.166g/cm³
• LogP: 5.05860
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 317.177964357
• Heavy Atom Count: 24
• Complexity: 385

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(C2=CC=CC=C2)C3=C(C=CC4=CC=CC=C43)O

Technology Process of 1-[Phenyl(piperidino)methyl]-2-naphthol

There total 16 articles about 1-[Phenyl(piperidino)methyl]-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

piperidine (110-89-4) + benzaldehyde (100-52-7) + β-naphthol (135-19-3) → 1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol (6278-04-2,500352-92-1,521960-31-6)

Guidance literature:

With Amberlite IRA-400 Cl resin; In ethanol; at 80 ℃; for 3h; Temperature; Reagent/catalyst;

DOI:10.1016/j.molstruc.2021.130861

Reference yield: 87.0%

N-<α-(benzotriazol-1-yl)phenylmethyl>piperidine (121238-80-0) + sodium 2-naphtholate (875-83-2) → 1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol (6278-04-2,500352-92-1,521960-31-6)

Guidance literature:

With 18-crown-6 ether; In toluene; for 12h; Heating;

DOI:10.1021/jo9903609

Reference yield: 80.0%

1-Benzylidene-piperidinium chloride + β-naphthol (135-19-3) → 1-[phenyl(piperidin-1-yl)methyl]naphthalen-2-ol (6278-04-2,500352-92-1,521960-31-6)

Guidance literature:

With triethylamine; In acetonitrile; for 12h; Ambient temperature;

DOI:10.1055/s-1996-4301

upstream raw materials:

piperidine

1-(α-aminobenzyl)-2-naphthol

1-((dimethylamino)(phenyl)methyl)naphthalen-2-ol

benzaldehyde

Downstream raw materials:

2-Hydroxy-1-(α-hydroxybenzyl)naphthalene

1-Ethoxy-1-phenyl-1-(2-hydroxy-naphthyl)-methan

1-benzyl-2-naphthol

(S)-(+)-1-(α-piperidylbenzyl)-2-naphthol